The epidemiology of neuropathic pain: an analysis of prevalence and associated factors in UK Biobank

The epidemiology of neuropathic pain: an analysis of prevalence and associated factors in UK Biobank
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神经性疼痛的流行病学：英国生物银行的患病率和相关因素分析

DOI：
10.1101/2022.07.26.22278063
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发表时间：
2022
期刊：
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影响因子：
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通讯作者：
Baskozos G
Baskozos G
中科院分区：
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文献类型：
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作者：
Baskozos G

文献摘要

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Objectives：本研究旨在验证这些特点在一个大的UK cohol.Methods：一个横断面分析进行了148,828英国生物银行参与者谁完成了详细的问卷调查慢性疼痛。在疼痛持续时间至少3个月的受试者中，使用神经性疼痛诊断问题（DN 4）区分神经性疼痛（NeuP）和非神经性疼痛（non-NeuP）。参与者还被确定为疼痛少于3个月或没有疼痛（NoCP）。采用多变量回归分析确定与NeuP相关的因素，并与非NeuP和NoCP进行比较。结果：76,095名参与者（51.1%）存在慢性疼痛。NeuP的总体患病率为9.2%。与NoCP相比，神经性疼痛与更差的健康相关生活质量、从事手工或个人服务型职业以及年龄更小显著相关。正如预期，NeuP与糖尿病和神经病变相关，但也与其他疼痛（骨盆疼痛、术后疼痛和偏头痛）和肌肉骨骼疾病（类风湿性关节炎、骨关节炎和纤维肌痛）相关。此外，与非NeuP相比，NeuP与肢体疼痛、更大的疼痛强度和更高的体重指数相关。与NoCP相比，女性与NeuP相关，而男性与NeuP相关，与non-NeuP.Conclusion相比：这是迄今为止最大的神经性疼痛的流行病学研究。结果证实，这种疾病在具有混合病因的中老年人群中很常见，并且与非神经性疼痛相比，对健康的影响更大。
Objectives:This study aimed to verify these characteristics in a large UK cohort.Methods:A cross-sectional analysis was conducted of 148,828 UK Biobank participants who completed a detailed questionnaire on chronic pain. The Douleur Neuropathique en Quatre Questions (DN4) was used to distinguish between neuropathic pain (NeuP) and non-neuropathic pain (non-NeuP) in participants with pain of at least 3 months' duration. Participants were also identified with less than 3 months' pain or without pain (NoCP). Multivariable regression was used to identify factors associated with NeuP compared with non-NeuP and NoCP, respectively.Results:Chronic pain was present in 76,095 participants (51.1%). The overall prevalence of NeuP was 9.2%. Neuropathic pain was significantly associated with worse health-related quality of life, having a manual or personal service type occupation, and younger age compared with NoCP. As expected, NeuP was associated with diabetes and neuropathy, but also other pains (pelvic, postsurgical, and migraine) and musculoskeletal disorders (rheumatoid arthritis, osteoarthritis, and fibromyalgia). In addition, NeuP was associated with pain in the limbs and greater pain intensity and higher body mass index compared with non-NeuP. Female sex was associated with NeuP when compared with NoCP, whereas male sex was associated with NeuP when compared with non-NeuP.Conclusion:This is the largest epidemiological study of neuropathic pain to date. The results confirm that the disorder is common in a population of middle-to older-aged people with mixed aetiologies and is associated with a higher health impact than non-neuropathic pain.