Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation
Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation
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DOI：
10.1364/ol.26.000893
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发表时间：
2001-06-15
期刊：
影响因子：
3.6
通讯作者：
Weissleder, R
中科院分区：
文献类型：
--
作者：
Ntziachristos, V;Weissleder, R
我们提出了一个归一化的玻恩展开，有利于荧光重建混浊，组织样介质。该算法可以是特别有用的荧光染料分布在体内的组织调查，因为它不需要绝对的光子场测量或造影剂管理之前的测量。这种独特的优势只能在荧光模式下实现。我们使用这种算法的三维图像和量化的吲哚菁荧光色素幻影，使用肚脐荧光断层成像仪开发的动物。(C)2001年美国光学学会。
We present a normalized Born expansion that facilitates fluorescence reconstructions in turbid, tissue-like media. The algorithm can be particularly useful for tissue investigations of fluorochrome distribution in vivo, since it does not require absolute photon-field measurements or measurements before contrast-agent administration. This unique advantage can be achieved only in fluorescence mode. We used this algorithm to three-dimensionally image and quantify an indocyanine fluorochrome phantom, using a navel fluorescence tomographic imager developed for animals. (C) 2001 Optical Society of America.