Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide
Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide
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DOI：
10.1021/ol403591c
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发表时间：
2014-02-21
期刊：
影响因子：
5.2
通讯作者：
Ley, Steven V.
中科院分区：
文献类型：
--
作者：
Battilocchio, Claudio;Hawkins, Joel M.;Ley, Steven V.
已经开发出一种用于亚硝酸盐水合的可持续流动化学工艺，其中亚硝酸盐水溶液通过含有市售无定形二氧化锰的柱。只需通过浓缩输出流即可获得产物，无需任何其他后处理步骤。所描述的协议快速、稳健、可靠且可扩展，并且已应用于广泛的底物，显示出高水平的化学耐受性。
A sustainable flow chemistry process for the hydration of nitrites, whereby an aqueous solution of the nitrite is passed through a column containing commercially available amorphous manganese dioxide, has been developed. The product is obtained simply by concentration of the output stream without any other workup steps. The protocol described is rapid, robust, reliable, and scalable, and it has been applied to a broad range of substrates, showing a high level of chemical tolerance.