The acute administration of the selective dopamine D(3) receptor antagonist SB-277011A reverses conditioned place aversion produced by naloxone precipitated withdrawal from acute morphine administration in rats.
The acute administration of the selective dopamine D(3) receptor antagonist SB-277011A reverses conditioned place aversion produced by naloxone precipitated withdrawal from acute morphine administration in rats.
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DOI：
10.1002/syn.20983
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Ashby CR Jr
中科院分区：
文献类型：
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作者：
Rice OV;Gardner EL;Heidbreder CA;Ashby CR Jr
我们研究了SB-277011 A（一种选择性D3受体拮抗剂）对雄性Sprague-Dawley大鼠急性吗啡给药后纳洛酮诱导戒断相关的条件性位置厌恶（CPA）反应的影响。吗啡（5.6 mg/kg i. p.）4 h后腹腔注射纳洛酮（0.3mg/kg）。并且在将动物置于试验装置的一个特定室中之前。所有动物均接受其中2项试验。在测量室偏好性前30分钟接受溶剂i. p.注射的动物中发生显著CPA。与溶媒（1 ml/kg i. p.去离子蒸馏水）处理动物相比，3 mg/kg i. p. SB-277011 A预处理动物（试验前30分钟）未显著改变CPA。相比之下，与溶剂处理的动物相比，用6、12或24 mg/kg i. p. SB-277011 A对动物进行急性预处理显著降低了CPA。事实上，12和24 mg/kg剂量的SB-277011 A显著增加了动物在与吗啡和纳洛酮配对的室中花费的时间。这些结果表明，D3受体的选择性拮抗作用减弱了由纳洛酮诱导的急性吗啡依赖戒断模型产生的CPA。
We examined the effect of SB-277011A, a selective D3 receptor antagonist, on the conditioned place aversion (CPA) response associated with naloxone-induced withdrawal from acute morphine administration in male Sprague-Dawley rats. Morphine (5.6 mg/kg i.p.) was given, followed 4 hrs later by naloxone (0.3 mg/kg i.p.) and prior to placing the animals in one specific chamber of the test apparatus. All animals were subjected to 2 of these trials. A significant CPA occurred in animals that received an i.p. injection of vehicle 30 minutes prior to the measurement of chamber preference. The pretreatment of animals (30 minutes prior to testing) with 3 mg/kg i.p. of SB-277011A did not significantly alter the CPA compared to animals treated with vehicle (1 ml/kg i.p. of deionized distilled water). In contrast, the acute pretreatment of animals with 6, 12 or 24 mg/kg i.p. of SB-277011A significantly decreased the CPA compared to vehicle-treated animals. In fact, the 12 and 24 mg/kg doses of SB-277011A significantly increased the time spent in the chamber where animals were paired with morphine and naloxone. These results suggest that the selective antagonism of D3 receptors attenuates the CPA produced by a model of naloxone-induced withdrawal from acute morphine dependence.