Functional analysis of Plasmodium falciparum merozoite antigens:: implications for erythrocyte invasion and vaccine development
Functional analysis of Plasmodium falciparum merozoite antigens:: implications for erythrocyte invasion and vaccine development
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DOI：
10.1098/rstb.2001.1010
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发表时间：
2002-01-29
期刊：
影响因子：
--
通讯作者：
Crabb, BS
中科院分区：
文献类型：
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作者：
Cowman, AF;Baldi, DL;Crabb, BS
疟疾是一个主要的人类健康问题，每年造成200多万人死亡。它是由疟原虫属的许多物种引起的，恶性疟原虫是最致命形式的病原体。因此，开发针对这种寄生虫的疫苗是一个优先事项。寄生虫生命周期的许多阶段是疫苗开发的目标。重要的候选抗原包括无性裂殖子阶段表面的蛋白质，这种形式侵入宿主红细胞。操纵疟原虫物种基因组的方法的发展使得能够构建功能获得和功能丧失突变体，并提供了分析寄生虫蛋白质作用的新策略。这为裂殖子抗原在红细胞侵袭中的作用提供了新的信息，也允许新的方法来解决其作为候选疫苗的潜力。
Malaria is a major human health problem and is responsible for over 2 million deaths per year. It is caused by a number of species of the genus Plasmodium, and Plasmodium falciparum is the causative agent of the most lethal form. Consequently, the development of a vaccine against this parasite is a priority. There are a number of stages of the parasite life cycle that are being targeted for the development of vaccines. Important candidate antigens include proteins on the surface of the asexual merozoite stage, the form that invades the host erythrocyte. The development of methods to manipulate the genome of Plasmodium species has enabled the construction of gain-of-function and loss-of-function mutants and provided new strategies to analyse the role of parasite proteins. This has provided new information on the role of merozoite antigens in erythrocyte invasion and also allows new approaches to address their potential as vaccine candidates.