Adenovirus infection of a renal allograft
Adenovirus infection of a renal allograft
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DOI：
10.1053/ajkd.2003.50133
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发表时间：
2003-03-01
影响因子：
13.2
通讯作者：
Nickeleit, V
中科院分区：
文献类型：
--
作者：
Asim, M;Chong-Lopez, A;Nickeleit, V
One month after renal transplantation, a 60-year-old man developed acute allograft dysfunction associated with gross hematuria and dysuria. Urinary cytological examination showed viral inclusion-bearing epithelial cells. A renal transplant biopsy specimen showed granulomatous interstitial nephritis, tubular necrosis, and ground glass-like intranuclear viral inclusion bodies in tubular cells caused by an adenovirus (ADV) infection. A reduction in baseline immunosuppressive therapy resulted in rapid normalization of allograft function and ultimately viral clearance. We report this case not only to illustrate an exceptional manifestation of an ADV infection in a renal allograft, but also to highlight the beneficial effect of reduction in immunosuppressive therapy on viral replication and clinical outcome.
