HHV-6 and seizures.
HHV-6 and seizures.
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发表时间：
2005-10
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影响因子：
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通讯作者：
N. Yamashita;T. Morishima
中科院分区：
文献类型：
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作者：
N. Yamashita;T. Morishima
人类疱疹病毒 6 (HHV-6) 是一种普遍存在的病毒，但可诱发多种神经系统疾病。最近，根据病毒学分析，一些癫痫发作被报告为新的 HHV-6 相关疾病。围产期感染 HHV-6 的新生儿可出现无热惊厥，这被认为是新生儿期急疹 (ES)。患有 ES 的婴儿也容易出现非典型热性惊厥。原发感染后，HHV-6 通常在中枢神经系统 (CNS) 中建立潜伏期，有时在海马体中重新激活，导致边缘脑炎和颞叶癫痫。这些由病毒再激活引起的 HHV-6 相关 CNS 疾病可能发生在免疫功能低下和免疫功能正常的宿主中。本文总结了儿童时期 HHV-6 相关的癫痫发作。
Human herpes virus-6 (HHV-6) is a ubiquitous virus, but one that can induce various neurological diseases. Recently, several seizures have been reported as new HHV-6-associated diseases based on virological analysis. Neonates who are perinatally infected with HHV-6 can develop afebrile seizures, which are considered to be exanthem subitum (ES) in the neonatal period. Infants with ES also tend to develop atypical febrile seizures. After primary infection, HHV-6 commonly establishes latency in the central nervous system (CNS) and sometimes reactivates in the hippocampus, causing limbic encephalitis and temporal lobe epilepsy. These HHV-6-associated CNS diseases due to virus reactivation can occur in both immunocompromised and immunocompetent hosts. This article summarizes HHV-6-associated seizures during childhood.