Evaluation of heterologous vaginal SHIV SF162p4 infection following vaccination with a polyvalent Clade B virus-like particle vaccine.
Evaluation of heterologous vaginal SHIV SF162p4 infection following vaccination with a polyvalent Clade B virus-like particle vaccine.
复制标题
接种多价 B 分支病毒样颗粒疫苗后异源阴道 SHIV SF162p4 感染的评估。
DOI：
10.1089/aid.2011.0351
复制
发表时间：
2012
影响因子：
1.5
通讯作者：
Ross,TedM
中科院分区：
文献类型：
--
作者：
McBurney,SeanP;Landucci,Gary;Forthal,DonaldN;Ross,TedM
HIV-1 感染的巨大多样性极大地阻碍了 HIV-1/艾滋病疫苗的成功开发。先前的疫苗工作已证明对 SHIV/SIV 感染的保护水平有限，但只有当攻击病毒与疫苗株直接匹配时才能观察到保护作用。由于不可能将疫苗毒株与自然界中的所有感染毒株直接匹配，因此有必要开发一种能够抵御异源病毒攻击的 HIV-1 疫苗。在这项研究中，我们研究了多价疫苗和共识疫苗预防异源 B 进化枝挑战的能力。恒河猴接种了 ConB 或 PolyB 病毒样颗粒疫苗。所有疫苗均具有高度免疫原性，在所有接种组中均发现针对 SIV Gag 的高滴度抗体。还观察到针对不同的 B 进化枝包膜组的抗体反应。接种疫苗后，非人灵长类动物 (NHP) 通过阴道途径接受 SHIVSF162p4 攻击。 PolyB 疫苗可使感染率降低 66.7%，如果感染未被阻断，病毒负荷也会减少两倍。 ConB 疫苗接种对感染率或病毒负荷没有影响。这些结果表明，与共识疫苗相比，多价进化枝匹配疫苗能够更好地预防异源攻击。
The vast diversity of HIV-1 infections has greatly impeded the development of a successful HIV-1/AIDS vaccine. Previous vaccine work has demonstrated limited levels of protection against SHIV/SIV infection, but protection was observed only when the challenge virus was directly matched to the vaccine strain. As it is likely impossible to directly match the vaccine strain to all infecting strains in nature, it is necessary to develop an HIV-1 vaccine that can protect against a heterologous viral challenge. In this study we investigated the ability of polyvalent and consensus vaccines to protect against a heterologous clade B challenge. Rhesus macaques were vaccinated with ConB or PolyB virus-like particle vaccines. All vaccines were highly immunogenic with high titers of antibody found in all vaccinated groups against SIV Gag. Antibody responses were also observed against a diverse panel of clade B envelopes. Following vaccination nonhuman primates (NHPs) were challenged via the vaginal route with SHIVSF162p4. The PolyB vaccine induced a 66.7% reduction in the rate of infection as well as causing a two log reduction in viral burden if infection was not blocked. ConB vaccination had no effect on either the infection rate or viral burden. These results indicate that a polyvalent clade-matched vaccine is better able to protect against a heterologous challenge as compared to a consensus vaccine.
登录
查看更多内容
HIV 1 型核衣壳蛋白中两个锌指基序的突变分析：对 Gag 前体蛋白水解加工和颗粒形成的影响。
影响因子：
1.5
作者：
Akiko Mizuno;Eiji Ido;Toshiyuki Goto;T. Kuwata;M. Nakai;Masanori Hayami
通讯作者：
Masanori Hayami
功能失活且具有免疫原性的 Tat、Rev 和 Nef DNA 疫苗源自撒哈拉以南 C 亚型人类免疫缺陷病毒 1 型共有序列。
影响因子：
5.5
作者：
T. Scriba;J. zur Megede;R. Glashoff;F. Treurnicht;S. Barnett;E. V. van Rensburg
通讯作者：
E. V. van Rensburg
影响因子：
5.4
作者：
Gao, F;Weaver, EA;Haynes, BF
通讯作者：
Haynes, BF
影响因子：
56.9
作者：
Harouse, JM;Gettie, A;Cheng-Mayer, C
通讯作者：
Cheng-Mayer, C
影响因子：
11.4
作者：
LEGRICE, SFJ;NAAS, T;SCHATZ, O
通讯作者：
SCHATZ, O