Family size, childhood infections and atopic diseases
Family size, childhood infections and atopic diseases
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DOI：
10.1136/thx.53.1.28
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发表时间：
1998-01-01
期刊：
影响因子：
10
通讯作者：
Seaton, A
中科院分区：
文献类型：
--
作者：
Bodner, C;Godden, D;Seaton, A
背景 - 这项研究探讨了引起过敏性疾病的儿童哮喘增加的原因，根据观察到的家庭规模与过敏性疾病或特应性之间的负相关关系，皮斯提出，常见儿童感染的减少可能是哮喘增加的原因。本研究旨在调查家庭规模与报告的过敏性疾病之间的关系，并检验儿童感染导致两者之间呈负相关的假设。 方法 - 数据来自 1964 年对阿伯丁当年 10 至 14 岁学童随机抽样的横断面调查。 2111 名受试者有调查时是否患有哮喘、湿疹或花粉症的记录，以及三岁之前和之后有麻疹、百日咳、水痘、风疹和流行性腮腺炎病史的记录。 结果 - 花粉症的风险（比值比 0.2，95% CI 0.1 至 0.8）和湿疹（OR 0.3， CI 0.1至0.7）与拥有三个或更多兄弟姐妹呈负相关，而哮喘风险（OR 0.4，CI 0.1至0.9）与拥有三个或更多弟弟妹妹呈负相关。兄弟姐妹总数的增加显示出对湿疹和花粉症的显着保护趋势。三岁后发现麻疹对哮喘的保护作用较弱（OR 0.5，CI 0.3至0.9) 和轻微;湿疹风险的增加与患有风疹或百日咳有关，而哮喘风险的增加则与患有水痘有关。三岁之前的感染数量与患过水痘有关。哮喘风险增加的比值比趋势 (p=0.025)。随着风疹、腮腺炎和水痘暴露的增加，湿疹和花粉症风险增加的比值比存在显着趋势。感染和特应性疾病之间的这些关系独立于年龄、性别、父亲的社会阶层和兄弟姐妹总数等潜在的混杂因素。 结论 - 这些数据增加了越来越多的证据，表明塔吉同胞身份可以在一定程度上预防特应性疾病。这似乎可以用常见的儿童感染来解释，这些感染与特应性疾病表现出相互冲突的关系，因为麻疹可能对哮喘有一定的保护作用，但孩子感染的病毒越多，他或她就越有可能患上特应性疾病。患有特应性疾病。同胞效应的解释可能在于其他方面，常见儿童感染的下降不太可能解释特应性疾病的增加。
Background - This study addresses the causes of the increases in childhood asthma send allergic disease, On the basis of an observed Inverse relationship between family size and allergic disease or atopy, it Peas been proposed that a fall in common childhood infections may have been responsible for the rise in asthma. This Study was undertaken to investigate the relationships between family size and reported allergic disease and to test the hypothesis that an inverse relationship between the two is a consequence of childhood infections.Methods - Data had ben obtained in a 1964 cross sectional survey of a random sample of Aberdeen schoolchildren aged between 10 and 14 in that year. Records of the presence sr absence of asthma, eczema, or hay fever at the time of the survey and a history of measles, pertussis, varicella, rubella, and mumps before and after the age of three gears were available for 2111 subjects.Results - The risks of hay fever (odds ratio 0.2, 95% CI 0.1 ao 0.8) and eczema (OR 0.3, CI 0.1 to 0.7) were inversely related to having had three or more older siblings, whilst the risk of asthma (OR 0.4, CI 0.1 to 0.9) was inversely related to having had three or more younger siblings, Increasing total numbers of Siblings showed a significant trends in protection against both eczema and hay fever, A weak protective effect against asthma was found for measles after the age of three (OR 0.5, CI 0.3 to 0.9) and slight; increases in the risk of eczema were associated with having had rubella or pertussis and of asthma with having had varicella, The number of infections before the age of three was associated with a significant. trend in the odds ratios towards increased risk of asthma (p=0.025). There were significant trends in the odds ratios towards greater risk of eczema and hay fever with increasing exposure to rubella, mumps, and varicella. These relations between infection and atopic diseases were independent of die potential confounding factors age, sex, father's social class, and total number of siblings.Conclusions - These data add to the accumulating evidence that membership of a Targe sibship confers some protection against atopic disease, This does slot appear to be explained by the common childhood infections which show conflicting relationships with atopic disease, in that measles may have some protective effect against asthma but the more infections a child has had, the more likely he or she is to have atopic disease. The explanation of the sibship effect is likely to lie elsewhere and the fall in common childhood infections is unlikely to explain the rise in atopic disease.