Exercise and nutritional interventions on sarcopenia and frailty in heart failure: a narrative review of systematic reviews and meta-analyses.
Exercise and nutritional interventions on sarcopenia and frailty in heart failure: a narrative review of systematic reviews and meta-analyses.
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本综述的目的是描述运动和营养干预作为治疗肌肉减少症和虚弱（即肌肉质量和身体功能下降）以及心力衰竭（HF）患者心肾代谢合并症风险的潜在贡献者的现有证据。主要来自横断面研究的证据表明，HF患者中肌肉减少症的患病率为男性37%，女性33%，这导致心脏恶病质、虚弱、生活质量降低和死亡率增加。在对35篇系统性综述和Meta分析进行评估后，我们探讨了阻力和有氧运动以及营养对肌肉减少症和虚弱以及生活质量的影响。大多数临床试验都集中在抵抗力，有氧运动和同步运动，以抵消HF患者肌肉质量和力量的进行性损失，同时通过利用维生素D和铁补充剂降低肿瘤坏死因子α（TNF-α），c反应蛋白（CRP）和白细胞介素-6（IL-6）水平也显示出有希望的效果。结合运动和营养对心力衰竭患者肌肉减少症和虚弱指标的共同影响的实验研究很少。迫切需要进一步研究和精心设计的临床试验，将HF患者同时运动和营养策略的合成代谢和抗分解代谢作用结合起来。
The purpose of this review is to describe the present evidence for exercise and nutritional interventions as potential contributors in the treatment of sarcopenia and frailty (i.e. muscle mass and physical function decline) and the risk of cardiorenal metabolic comorbidity in people with heart failure (HF). Evidence primarily from cross‐sectional studies suggests that the prevalence of sarcopenia in people with HF is 37% for men and 33% for women, which contributes to cardiac cachexia, frailty, lower quality of life, and increased mortality rate. We explored the impact of resistance and aerobic exercise, and nutrition on measures of sarcopenia and frailty, and quality of life following the assessment of 35 systematic reviews and meta‐analyses. The majority of clinical trials have focused on resistance, aerobic, and concurrent exercise to counteract the progressive loss of muscle mass and strength in people with HF, while promising effects have also been shown via utilization of vitamin D and iron supplementation by reducing tumour necrosis factor‐alpha (TNF‐a), c‐reactive protein (CRP), and interleukin‐6 (IL‐6) levels. Experimental studies combining the concomitant effect of exercise and nutrition on measures of sarcopenia and frailty in people with HF are scarce. There is a pressing need for further research and well‐designed clinical trials incorporating the anabolic and anti‐catabolic effects of concurrent exercise and nutrition strategies in people with HF.
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影响因子：
18.2
作者：
Groenewegen A;Rutten FH;Mosterd A;Hoes AW
通讯作者：
Hoes AW
影响因子：
18.2
作者：
Bhella, Paul S.;Prasad, Anand;Levine, Benjamin D.
通讯作者：
Levine, Benjamin D.
影响因子：
8.3
作者：
Fukuta, Hidekatsu;Goto, Toshihiko;Ohte, Nobuyuki
通讯作者：
Ohte, Nobuyuki
影响因子：
3.9
作者：
Alcaide-Aldeano, Alex;Garay, Alberto;Moliner, Pedro
通讯作者：
Moliner, Pedro
影响因子：
1.6
作者：
Guo R;Wen Y;Xu Y;Jia R;Zou S;Lu S;Liu G;Cui K
通讯作者：
Cui K