A population-based case-control study of isolated ocular coloboma
A population-based case-control study of isolated ocular coloboma
复制标题
DOI：
10.1080/09286580590969699
复制
发表时间：
2005-06-01
影响因子：
1.8
通讯作者：
Czeizel, AE
中科院分区：
文献类型：
--
作者：
Vogt, G;Puhó, E;Czeizel, AE
目的：探讨孤立性眼缺损（主要是虹膜缺损）的可能病因。方法：使用1980 - 2002年匈牙利先天性先天畸形病例对照监测数据集。暴露数据和家族史基于（1）前瞻性医疗记录，（2）回顾性母亲信息，和（3）地区护士在家访时获得的信息。结果：46例中40例为虹膜缺损，19例为双侧虹膜缺损。4.3%（2/46）的病例有家族史，提示有遗传性。发现孤立性眼缺损与羟乙基芸香苷治疗之间存在相关性（经调整的POR，95% CI：5.4，2.2-12.9）。孤立性眼缺损与甲状腺功能减退症之间存在另一种相关性（校正OR，95%CI = 12.6，3.0-52.7），但仅基于2例病例。结论：有必要研究这些眼缺损发生的可预防的环境因素。
Alms: To attempt the detection of possible etiological factors in the origin of isolated ocular, mainly iris coloboma. Methods: The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 19802002, was used. Exposure data and family history were based on (1) prospective medical records, (2) retrospective maternal information, and (3) information obtained by regional nurses at home visit. Results: Of 46 cases, 40 were affected with iris coloboma and 19 had bilateral manifestation. The positive family history indicated a hereditary origin in 4.3% (2/46) of cases. An association was found between the isolated ocular coloboma and hydroxyethylrutoside treatment (adjusted POR with 95% Cl: 5.4, 2.2-12.9). Another association was seen between isolated ocular coloboma and hypothyroidism (adjusted OR with 95% CI = 12.6, 3.0-52.7), but it was based only on two cases. Conclusions: It is necessary to study the preventable environmental factors in the origin of these ocular defects.