Evaluation of plasma skin regeneration technology in low-energy full-facial rejuvenation
Evaluation of plasma skin regeneration technology in low-energy full-facial rejuvenation
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DOI：
10.1001/archderm.143.2.168
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发表时间：
2007-02-01
影响因子：
--
通讯作者：
Dover, Jeffrey S.
中科院分区：
文献类型：
--
作者：
Bogle, Melissa A.;Arndt, Kenneth A.;Dover, Jeffrey S.
Objective: To evaluate the use of multiple, low-energy, full-face plasma skin regeneration treatments.Design: Plasma skin regeneration delivers energy to the skin through plasma pulses induced by passing radiofrequency into nitrogen gas. Single-treatment, high-energy, 1-pass treatments have been demonstrated to achieve good results with an excellent safety profile. Eight volunteers underwent full-face treatments every 3 weeks, for a total of 3 treatments, using energy settings of 1.2 to 1.8 J. Before each subsequent treatment, the quality of regenerated epidermis, the degree of downtime, and erythema were recorded. Full-thickness skin biopsy specimens were obtained from 6 patients before treatment and 90 days following the last treatment. Patients were seen for follow-up 4 days after each treatment and 30 and 90 days after the third treatment.Results: Three months after treatment, investigators found a 37% reduction in facial rhytids and study participants noted a 68% improvement in overall facial appearance. Reepithelialization was complete in 4 days. Patients assessed erythema to persist an average of 6 days after treatment. Epidermal regeneration from the first treatment was longer than from the following treatments (9 vs 4 and 5 days, respectively). One patient developed localized hyperpigmentation after the first treatment, which resolved by follow-up at day 30. No scarring or hypopigmentation occurred. A histologic evaluation 3 months after treatment revealed a band of new collagen at the dermoepidermal junction with less dense elastin in the upper dermis. The mean depth of new collagen was 72.3 mu m.Conclusions: Plasma skin regeneration using the multiple low-energy treatment technique allows significant successful treatment of photodamaged facial skin with minimal downtime. Results are comparable to a single high-energy treatment, but with less healing time.
