Using Drosophila melanogaster as a suitable platform for drug discovery from natural products in inflammatory bowel disease.
Using Drosophila melanogaster as a suitable platform for drug discovery from natural products in inflammatory bowel disease.
复制标题
DOI：
10.3389/fphar.2022.1072715
复制
发表时间：
2022
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
炎症性肠病（IBD）是一种慢性且危及生命的炎症性疾病，可发生在人类肠道的多个部位，并且已成为发病率不断增加的世界性问题。由于其早期症状轻微，大多数不会引起人们的注意，并可能造成更严重的后果。迫切需要新的疗法来预防疾病进展。天然产物活性成分多样、生物活性多样、毒副作用低，是防治肠道炎症性疾病的新选择。由于多种遗传模型、较少的伦理问题、与哺乳动物的保守信号通路以及较低的维护成本，果蝇已成为研究IBD机制和治疗策略的合适模型。在此，我们回顾了苍蝇模型作为药物发现筛选平台的优势，描述了哺乳动物和苍蝇之间作为IBD治疗靶点的保守分子途径，剖析了果蝇模型在IBD研究中的可行性，并总结了利用苍蝇治疗IBD的天然产物。这篇综述全面阐述了苍蝇作为评估植物化学物质对 IBD 治疗潜力的完美模型的好处。
Inflammatory bowel disease (IBD) is a chronic and life-treating inflammatory disease that can occur in multiple parts of the human intestine and has become a worldwide problem with a continually increasing incidence. Because of its mild early symptoms, most of them will not attract people’s attention and may cause more serious consequences. There is an urgent need for new therapeutics to prevent disease progression. Natural products have a variety of active ingredients, diverse biological activities, and low toxicity or side effects, which are the new options for preventing and treating the intestinal inflammatory diseases. Because of multiple genetic models, less ethical concerns, conserved signaling pathways with mammals, and low maintenance costs, the fruit fly Drosophila melanogaster has become a suitable model for studying mechanism and treatment strategy of IBD. Here, we review the advantages of fly model as screening platform in drug discovery, describe the conserved molecular pathways as therapetic targets for IBD between mammals and flies, dissect the feasibility of Drosophila model in IBD research, and summarize the natural products for IBD treatment using flies. This review comprehensively elaborates that the benefit of flies as a perfact model to evaluate the therapeutic potential of phytochemicals against IBD.
ClC-c 通过 EGFR 信号通路调节果蝇肠道干细胞的增殖。
影响因子：
8.5
作者：
Huang J;Sheng X;Zhuo Z;Xiao D;Wu K;Wan G;Chen H
通讯作者：
Chen H
影响因子：
3.7
作者：
Strand M;Micchelli CA
通讯作者：
Micchelli CA