Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention
Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention
复制标题
肠道微生物组发酵决定运动预防糖尿病的功效
DOI：
10.1016/j.cmet.2019.11.001
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发表时间：
2020-01-07
期刊：
影响因子：
29
通讯作者：
Xu, Aimin
中科院分区：
文献类型：
--
作者：
Liu, Yan;Wang, Yao;Xu, Aimin
运动是糖尿病管理的有效策略，但受到运动抵抗现象的限制（即，缺乏运动或对运动的不良反应对代谢健康的影响）。在这里，在39名未接受过药物治疗的糖尿病前期男性中，我们发现运动引起的肠道微生物群变化与葡萄糖稳态和胰岛素敏感性的改善密切相关（clinicaltrials.gov entry NCT03240978）。响应者的微生物组表现出增强的短链脂肪酸和支链氨基酸的生物合成能力，而非响应者的微生物组的特征在于代谢有害化合物的产生增加。来自应答者而非应答者的粪便微生物移植模拟了运动对减轻肥胖小鼠胰岛素抵抗的作用。此外，整合基线微生物特征的机器学习算法准确预测了另外30名受试者对运动的个性化血糖反应。这些发现提高了通过针对肠道微生物群来最大限度地发挥运动益处的可能性。
Exercise is an effective strategy for diabetes management but is limited by the phenomenon of exercise resistance (i.e., the lack of or the adverse response to exercise on metabolic health). Here, in 39 medication-naive men with prediabetes, we found that exercise-induced alterations in the gut microbiota correlated closely with improvements in glucose homeostasis and insulin sensitivity entry (clinicaltrials.gov entry NCT03240978). The microbiome of responders exhibited an enhanced capacity for biosynthesis of short-chain fatty acids and catabolism of branched-chain amino acids, whereas those of non-responders were characterized by increased production of metabolically detrimental compounds. Fecal microbial transplantation from responders, but not non-responders, mimicked the effects of exercise on alleviation of insulin resistance in obese mice. Furthermore, a machine-learning algorithm integrating baseline microbial signatures accurately predicted personalized glycemic response to exercise in an additional 30 subjects. These findings raise the possibility of maximizing the benefits of exercise by targeting the gut microbiota.