Retention of enzyme gene duplicates by subfunctionalization
Retention of enzyme gene duplicates by subfunctionalization
复制标题
DOI：
10.1016/s0141-8130(03)00059-x
复制
发表时间：
2003-11-01
影响因子：
8.2
通讯作者：
Liberles, DA
中科院分区：
文献类型：
--
作者：
Braun, FN;Liberles, DA
复制-退化-互补（DDC）描述了一个过程，通过这个过程，一个多效性祖先基因的进化复制品在它们之间分割了祖先的多种功能（即亚功能化），这最终阻碍了假基因形成的速度。明确关注酶样多效性功能，我们模拟DDC驱动的重复之间的序列分歧。该模型采用了一个理想化的序列功能映射，其中酶-底物结合亲和力与结合口袋的三级结构的疏水性与极性（HP）氨基酸组成有关。在这个意义上，一个透明的耦合之间的物理化学功能的酶和序列进化。(C)2003 Elsevier B. V.保留所有权利。
Duplication-degeneration-complementation (DDC) describes a process by which evolving duplicates of a pleiotropic ancestral gene divide up the multiple functions of the ancestor between them (i.e. subfunctionalize), and this ultimately frustrates the rate of pseudogene formation. Focusing explicitly on enzyme-like pleiotropic function, we model DDC driven by sequence divergence between duplicates. The model incorporates an idealized sequence-function mapping in which enzyme-substrate binding affinity is related to hydrophobic versus polar (HP) amino-acid composition of tertiary structure about the binding pocket. In this sense, a transparent coupling between physical-chemical function of an enzyme and sequence evolution is presented. (C) 2003 Elsevier B.V. All rights reserved.