Fever, antipyretics and serum iron levels in rabbits.
Fever, antipyretics and serum iron levels in rabbits.
复制标题
兔子的发烧、退烧药和血清铁水平。
DOI：
10.1016/0014-2999(82)90252-7
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发表时间：
1982
影响因子：
5
通讯作者：
A. Brugger
中科院分区：
文献类型：
--
作者：
A. Cremades;F. García;J. del Río;A. Brugger
脑室内（i.c.v.）注射细菌内毒素（志贺氏菌）可使家兔深部体温升高。多粘菌素B部分抑制体温升高（P），酮洛芬完全抑制体温升高（K）。全身注射细菌内毒素（志贺菌或伤寒沙门氏菌）引起家兔体温升高，多粘菌素B可部分阻断，酮洛芬可完全拮抗。伤寒沙门氏菌内毒素处理的家兔血清铁浓度下降，注射酮洛芬、多粘菌素B、吲哚美辛和酮洛芬加内毒素后血清铁浓度升高（En）。然而，血清铁水平的总增加量在解热药后高于酮洛芬加内毒素治疗后。这些结果表明，解热药拮抗由细菌内毒素引起的体温升高和血清铁浓度下降，并且本研究中用于诱导解热的所有药物均增加血清铁水平。
The intracerebroventricular (i.c.v.) injection of bacterial endotoxin (Shigella dysenteriae) produces a rise in deep-body temperature in rabbits. The increase in body temperature was partially inhibited by polymyxin B (P), and completely suppressed by ketoprofen (K). The systemic injection of bacterial endotoxins (Shigella dysenteriae or Salmonella typhosa) elicited an elevation of body temperature in rabbits which was partially blocked by polymyxin B and completely antagonized by ketoprofen. Serum iron concentration fell in rabbits treated with Salmonella typhosa endotoxin and rose after injections of ketoprofen, polymyxin B, indomethacin and ketoprofen plus endotoxin (En). However, the total increases in serum iron levels were higher after antipyretics than after ketoprofen plus endotoxin treatment. These results show that the antipyretics antagonized the rise in body temperature and the fall in serum iron concentration induced by bacterial endotoxin and all the drugs used in this study to induce antipyresis increased serum iron levels.