Developmental changes in rat blood choline concentration.
Developmental changes in rat blood choline concentration.
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大鼠血液胆碱浓度的发育变化。
DOI：
10.1042/bj1980565
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Wurtman,RJ
中科院分区：
文献类型：
--
作者：
Zeisel,SH;Wurtman,RJ
1.新生大鼠的血清胆碱浓度极高，并随着大鼠的成熟而下降，直到20日龄时达到成年值。2.大鼠乳汁是胆碱的丰富来源，与喂养的同窝出生大鼠相比，拒绝母乳喂养的幼鼠血清胆碱浓度显著降低。我们的结论是饮食摄入胆碱有助于维持高血清胆碱浓度的新生大鼠。3.在体内，胆碱消失的半衰期为70分钟。它被转化为甜菜碱，磷酸胆碱和磷脂酰胆碱。磷酸胆碱形成的速率在3日龄和10日龄大鼠中相同（3.3 mumol/h），而甜菜碱形成的速率在较年轻的动物中较慢（3日龄为0.15 mumol/h，10日龄为0.69 mumol/h）。在体外，胆碱氧化酶活性[胆碱脱氢酶（EC 1.1.99.1）和甜菜碱醛脱氢酶（EC 1.2.1.8）]在出生至40日龄之间增加。年龄相关的加速胆碱转化为甜菜碱可能倾向于减少未酯化的胆碱浓度在大鼠。
1. Serum choline concentration in the newborn rat is extremely high and declines as the rat matures until adult values are attained at 20 days of age. 2. Rat milk is a rich source of choline, and rat pups denied access to milk had significantly lower serum choline concentrations than did fed littermates. We conclude that dietary intake of choline contributes to the maintenance of high serum choline concentrations in the neonatal rat. 3. In vivo, choline disappears with a half-life of 70 min. It is converted into betaine, phosphocholine and phosphatidylcholine. The rate of phosphocholine formation is identical in 3- and 10-day-old rats (3.3 mumol/h), whereas the rate of betaine formation is slower in younger animals (0.15 mumol/h at 3 days versus 0.69 mumol/h at 10 days). In vitro, choline oxidase activity [choline dehydrogenase (EC 1.1.99.1) and betaine aldehyde dehydrogenase (EC 1.2.1.8)] increased between birth and 40 days of age. The age-related acceleration in choline's conversion into betaine probably tends to diminish unesterified choline concentration in the rat.