ANALYSIS OF THE OUTCOME OF IDIOPATHIC INFLAMMATORY MYOPATHIES WITH PARTICULAR EMPHASIS ON MUSCLE CAPILLARY DAMAGE
ANALYSIS OF THE OUTCOME OF IDIOPATHIC INFLAMMATORY MYOPATHIES WITH PARTICULAR EMPHASIS ON MUSCLE CAPILLARY DAMAGE
复制标题
DOI：
10.3109/03009749309095142
复制
发表时间：
1993-01-01
影响因子：
2.1
通讯作者：
URBANOMARQUEZ, A
中科院分区：
文献类型：
--
作者：
CASADEMONT, J;GRAU, JM;URBANOMARQUEZ, A
本研究的目的是评估我们的特发性炎症性肌病 (IIM) 系列的结果，特别考虑毛细血管损伤作为预后指标。我们根据肌肉活检中是否存在毛细血管损伤对诊断为 IIM 的患者进行了分类，并通过生存分析统计技术确定了他们的结果。我们对患者的随访似乎表明，没有毛细血管损伤的患者表现出一种更惰性的 IIM，对治疗的反应更慢。毛细血管损伤的存在表明疾病更加急性，发病率和死亡率更高，但对免疫抑制的反应更快。毛细血管损伤的存在或不存在似乎决定了两种形式的 IIM 的不同结果和预后。
The objective of this study was to assess the outcome of our series of idiopathic inflammatory myopathies (IIM) with special consideration of capillary damage as a prognostic indicator. We have classified our series of patients with the diagnosis of IIM according to the presence or absence of capillary damage in muscle biopsies, and determined their outcome by means of survival analysis statistical techniques. The follow-up of our patients seems to demonstrate that the patients without capillary damage present a more indolent form of IIM, with a slower response to treatment. The presence of capillary damage indicates a more acute disease, with more morbidity and mortality, but with a faster response to immunosuppression. The presence or absence of capillary damage seems to determine two forms of IIM with differentiated outcome and prognostic.