Total synthesis and structure assignment of papuamide B, A potent marine cyclodepsipeptide with anti-HIV properties
Total synthesis and structure assignment of papuamide B, A potent marine cyclodepsipeptide with anti-HIV properties
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DOI：
10.1002/anie.200705557
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发表时间：
2008-01-01
影响因子：
16.6
通讯作者：
Ma, Dawei
中科院分区：
文献类型：
--
作者：
Xie, Weiqing;Ding, Derong;Ma, Dawei
Guinea collections of the marine sponges Theonella mirabilis and Theonella swinhoei.[1] Both compounds exhibit a strong inhibitory effect on the infection of human T-lymphoblastoid cells by HIV-1RF invitro, with an EC50 value of about 4 ng mLÀ1. Similar biological activities were also observed for other cyclic depsipeptides isolated from different marine sponges, namely: callipeltinA,[2] neamphamide A,[3] and mirabamides A–D.[4] Given this background, it is not surprising that recent intensive efforts have been directed towards gaining synthetic access to these natural products.[5–7] These efforts have led to the successful establishment of the stereochemistry of some sterogenic centers within this class of compounds.[5] However, none of these molecules have yet been assembled. Herein, we report our synthetic strategy towards papuamide B.[8]
