The nucleotide sequence of the adult chicken alpha-globin genes.
The nucleotide sequence of the adult chicken alpha-globin genes.
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DOI：
10.1016/s0021-9258(18)32669-3
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发表时间：
1983-04
期刊：
影响因子：
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通讯作者：
J. Dodgson;J D Engel
中科院分区：
文献类型：
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作者：
J. Dodgson;J D Engel
完整的核苷酸序列报告的两个成年鸡α-珠蛋白基因，α A和α D。这两个基因在成人红细胞中分别以3：1的比例表达，差异很大，表明它们已经分别进化了数亿年。虽然这些基因在鸡的染色体上紧密相连，但确定的核苷酸序列清楚地排除了任何最近的基因转换事件。正如预期的那样，两个基因都含有两个相对较短的插入序列。α D基因的3'内含子开始于二核苷酸GC而不是典型的GT。广泛的侧翼序列被报道为两个基因。将这两个基因的染色体序列相互比较，并与测序的哺乳动物α-珠蛋白基因进行比较。
The complete nucleotide sequence is reported of the two adult chicken alpha-globin genes, alpha A and alpha D. These two genes, expressed in a 3:1 ratio, respectively, in adult red cells, are widely divergent, suggesting that they have evolved separately for several hundred million years. Although the genes are closely linked in the chicken chromosome, the nucleotide sequences determined clearly rule out any recent gene conversion events. As expected, both genes contain two relatively short intervening sequences. The 3' intron of the alpha D gene begins with the dinucleotide GC rather than the typical GT. Extensive flanking sequences are reported for both genes. The chromosomal sequences of the two genes are compared to each other and to sequenced mammalian alpha-globin genes.