Cortical activation during color discrimination task in macaques as revealed by positron emission tomography
Cortical activation during color discrimination task in macaques as revealed by positron emission tomography
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DOI：
10.1016/j.neulet.2010.08.040
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发表时间：
2010-11-05
影响因子：
2.5
通讯作者：
Watanabe, Yasuyoshi
中科院分区：
文献类型：
--
作者：
Katsuyama, Narumi;Imamura, Kazuyuki;Watanabe, Yasuyoshi
生理和病变研究表明，前下颞叶（IT）皮层（aITC）参与猕猴的色觉。然而，一些使用清醒猴子的功能成像研究与aITC参与色觉相矛盾。因此，在大多数成像研究中，在固定任务期间观察到皮层激活。然而，由于aITC的神经元活动是高度受行为任务，它是可取的调查皮层活动在颜色辨别任务，以确定的功能作用的aITC在猕猴的色觉。在这项研究中，我们调查了猕猴的皮层活动的aITC颜色辨别过程中的正电子发射断层扫描。两只猴子接受了颜色辨别任务的训练。通过比较颜色辨别和杠杆释放任务中的活动，研究了参与颜色加工的皮层区域。除了V4区和后IT皮层（pITC），我们发现在前IT回的颜色相关的活动。一致的激活，观察到在该地区后的前内侧颞沟（AMTS），虽然确切的位置和激活的大小不同的猴子和半球。我们还发现，在上级颞沟（STS）的前部的颜色相关的活动，表明其参与色觉。本研究结果显示，aITC参与猕猴的色觉功能成像技术。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Physiological and lesion studies have shown that the anterior inferior temporal (IT) cortex (aITC) is involved in the color vision of macaque monkeys. However, some functional imaging studies using awake monkeys contradicted the involvement of aITC in color vision. Thus, in most of the imaging studies, cortical activation has been observed during a fixation task. However, because the neuronal activity of aITC is highly affected by the behavioral task, it is desirable to investigate cortical activity during a color discrimination task to determine the functional role of aITC in the color vision of macaque monkeys. In this study, we investigated the cortical activity of aITC of macaque monkeys during color discrimination by positron emission tomography. Two monkeys were trained in a color discrimination task. Cortical areas involved in color processing were investigated by comparing activities during the color discrimination and lever release tasks. In addition to area V4 and the posterior IT cortex (pITC), we found color-related activities in the anterior IT gyrus. Consistent activation was observed in the region posterior to the anterior medial temporal sulcus (AMTS), although the exact location and the size of activations differed between monkeys and hemispheres. We also found color-related activities in the anterior portion of the superior temporal sulcus (STS), suggesting its involvement in the color vision. The present results revealed that aITC is involved in the color vision of macaque monkeys by a functional imaging technique. (C) 2010 Elsevier Ireland Ltd. All rights reserved.