Delay or inhibition of rat lens opacification using pantethine and WR-77913
Delay or inhibition of rat lens opacification using pantethine and WR-77913
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DOI：
10.1006/exer.1996.0009
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发表时间：
1996-01-01
影响因子：
3.4
通讯作者：
Steele, JE
中科院分区：
文献类型：
--
作者：
Clark, JI;Livesey, JC;Steele, JE
泛硫乙胺和氨基硫代磷酸酯WR-77913在五种动物模型中保护晶状体免受白内障形成过程中增加的光散射和混浊：（1）辐射，（2）亚硒酸盐，（3）半乳糖，（4）链脲佐菌素和（5）皇家外科学院。在辐射或亚硒酸盐模型中，通过单次注射Na 2SeO 3或单次暴露于15戈伊（格雷）γ辐射，在引发白内障前15至30分钟给予每种测试试剂。在半乳糖、链脲佐菌素和皇家外科医师学院模型中，其中白内障发生性损伤是连续的，需要重复给予泛硫乙胺和WR-77913。结果表明，使用泛硫乙胺或WR-77913的全身给药可以延迟或抑制与各种生理和生化机制相关的蛋白质聚集和透镜混浊。(C)1996年学术出版社
Pantethine and the amino phosphorothioate, WR-77913, protected lenses against increased light scattering and opacification during cataract formation in five animal models: (1) radiation, (2) selenite, (3) galactose, (4) streptozotocin and (5) Royal College of Surgeons. In the radiation or selenite models, each test reagent was administered 15 to 30 min prior to initiation of cataract by a single injection of Na2SeO3 or a single exposure to 15 Gy (gray) gamma radiation. In the galactose, streptozotocin and Royal College of Surgeons models where the cataractogenic insult was continuous, repeated administrations of pantethine and WR-77913 were necessary. The results suggested that protein aggregation and lens opacification associated with a variety of physiological and biochemical mechanisms can be delayed or inhibited using a systemic administration of pantethine or WR-77913. (C) 1996 Academic Press Limited