Genetic variation in CD83 and risks of cervical and vulvar cancers: A population-based case-control study
Genetic variation in CD83 and risks of cervical and vulvar cancers: A population-based case-control study
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DOI：
10.1016/j.ygyno.2011.11.017
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发表时间：
2012-03-01
影响因子：
4.7
通讯作者：
Schwartz, Stephen M.
中科院分区：
文献类型：
--
作者：
Bodelon, Clara;Madeleine, Margaret M.;Schwartz, Stephen M.
目标。CD83糖蛋白是树突状细胞成熟的标志，可能有助于T细胞对致癌的人乳头瘤病毒（HPV）感染的反应。CD83的单核苷酸多态性（snp）是否影响hpv相关生殖器癌的风险尚未得到充分的研究。我们在西雅图-普吉特海湾地区进行了一项基于人群的病例对照研究，调查了CD83区域的常见遗传变异是否与宫颈癌和外阴癌的风险相关。在886例宫颈、517例外阴和1100例对照的CD83区共检测到17个标签snp。计算优势比（OR）和95%置信区间（Cl）来评估宫颈癌和外阴癌的风险。我们还探讨了标签snp与吸烟之间的相互作用。CD83染色体区域的标签snp与宫颈癌或外阴癌的风险无关。标签snp rs853360与宫颈鳞状细胞癌（SCC）风险降低相关（OR=0.80; 95% Cl: 0.66-0.98）。我们的研究结果并不表明CD83的常见遗传变异与子宫颈癌或外阴癌有关。标签snp rs853360与宫颈SCC风险之间的关联可能是偶然的。如果更大的或合并的研究证实了我们的结果，CD83对hpv相关癌症的风险影响很小或没有影响。Elsevier Inc.出版。
Objectives. The CD83 glycoprotein is a marker of dendritic cell maturation that may contribute to the T cell response to oncogenic human papillomavirus (HPV) infection. Whether single nucleotide polymorphisms (SNPs) in CD83 influence the risk of HPV-related genital cancers has not been adequately studied. We investigated whether the common genetic variation of the CD83 region was associated with the risks of cervical and vulvar cancers in a population-based case-control study conducted in the Seattle-Puget Sound Region.Methods. A total of 17 tagSNPs were genotyped in the CD83 region of 886 cervical cases, 517 vulvar cases and 1100 controls. Odds ratio (OR) and 95% confidence intervals (Cl) were computed to assess the risk of cervical and vulvar cancers. The interaction between the tagSNPs and cigarette smoking was also explored.Results. TagSNPs in the CD83 chromosomal region were not associated with risk of either cervical or vulvar cancer. TagSNP rs853360 was associated with a decreased risk of cervical squamous cell carcinoma (SCC) (OR=0.80; 95% Cl: 0.66-0.98).Conclusions. Our results do not suggest that the common genetic variation of CD83 is related to cervical or vulvar cancers. The association between tagSNP rs853360 and risk of cervical SCC is likely to be due to chance. If larger or pooled studies confirm our results, CD83 has little or no influence in the risk of HPV-related cancers. Published by Elsevier Inc.