Individual differences in rat locomotor activity are diminished by nicotine through stimulation of central nicotinic acetylcholine receptors
Individual differences in rat locomotor activity are diminished by nicotine through stimulation of central nicotinic acetylcholine receptors
复制标题
DOI：
10.1016/s0031-9384(00)00413-3
复制
发表时间：
2001-01-01
影响因子：
2.9
通讯作者：
Besheer, J
中科院分区：
文献类型：
--
作者：
Bevins, RA;Besheer, J
越来越多的研究集中在隔离因素，预测或改变个体差异的行为和神经过程介导的滥用药物的影响。在此框架内，本报告评估了尼古丁的个体差异和运动效应。对大鼠进行了筛选，以确定新环境诱导的活动。大鼠，这是更积极的初始环境暴露，仍然更活跃，即使在7个额外的30分钟暴露于相同的环境。用尼古丁-二-D酒石酸盐（1 mg/kg，sc）处理破坏了这种作用。无论尼古丁是抑制自发活动（首次给药）还是刺激自发活动（第七次和第八次给药），都会发生尼古丁对个体差异的破坏。美加明（1 mg/kg）可完全阻断尼古丁的抑制和兴奋作用，但六甲双铵（10 mg/kg）不能。此外，美加明恢复了尼古丁诱导的个体差异破坏;六烃季铵没有影响。这种数据模式表明，急性和慢性尼古丁对个体差异的破坏性影响是由神经烟碱乙酰胆碱（nACh）受体介导的。(C)2001 Elsevier Science Inc. All rights reserved.
An increasing body of research has focused on isolating factors that predict or alter individual differences in the behavioral and neural processes mediating the effects of abused drugs. Within this framework, the current report assessed individual differences and the locomotor effect of nicotine. Rats were screened for activity induced by a novel environment. Rats, which were more active to initial environment exposure, remained more active even after seven additional 30-min exposures to the same environment. Treatment with nicotine-di-D tartrate (1 mg/kg, sc) disrupted this effect. This nicotine disruption of individual differences occurred whether nicotine suppressed locomotor activity (initial administration) or stimulated locomotor activity (seventh and eighth administration). Mecamylamine (1 mg/kg), but not hexamethonium (10 mg/kg), completely blocked the suppressant and stimulant effects of nicotine. Further, mecamylamine restored the nicotine-induced disruption of individual differences; hexamethonium had no effect. This data pattern suggests that the disruptive effects of acute and chronic nicotine on individual differences were mediated by neural nicotinic acetylcholine (nACh) receptors. (C) 2001 Elsevier Science Inc. All rights reserved.