EFFECTS OF ETHANOL ON THE CONTRACTILE FUNCTION OF THE HEART - A REVIEW
EFFECTS OF ETHANOL ON THE CONTRACTILE FUNCTION OF THE HEART - A REVIEW
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DOI：
10.1111/j.1530-0277.1994.tb00891.x
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发表时间：
1994-02-01
影响因子：
3.2
通讯作者：
RUBIN, E
中科院分区：
文献类型：
--
作者：
THOMAS, AP;ROZANSKI, DJ;RUBIN, E
慢性乙醇消耗导致心脏收缩功能的许多改变，并且是心肌病的主要原因。乙醇还具有通过与心肌细胞直接相互作用介导的急性负性肌力作用，尽管该作用通常被体内儿茶酚胺释放增强引起的间接作用所掩盖。本文就乙醇对心脏收缩功能的影响作一综述。在心肌细胞中受乙醇影响的具体目标进行了讨论的潜在机制的抑郁症的收缩性导致的急性和慢性乙醇的行动。
Chronic ethanol consumption leads to a number of alterations in the contractile function of the heart and is a leading cause of cardiomyopathy. Ethanol also has an acute negative inotropic effect mediated by direct interaction with cardiac muscle cells, although this action is often masked by indirect actions resulting from enhanced release of catecholamines in vivo. This article reviews the effects of ethanol on the contractile function of the heart. The specific targets affected by ethanol in cardiac muscle cells are discussed in terms of potential mechanisms underlying the depressions of contractility resulting from both acute and chronic actions of ethanol.