Highly Stereoselective Metal-Free Oxyaminations Using Chiral Hypervalent Iodine Reagents
Highly Stereoselective Metal-Free Oxyaminations Using Chiral Hypervalent Iodine Reagents
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DOI：
10.1002/anie.201107703
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发表时间：
2012-01-01
影响因子：
16.6
通讯作者：
Wirth, Thomas
中科院分区：
文献类型：
--
作者：
Farid, Umar;Wirth, Thomas
环和I：高价碘化合物避免了许多基于过渡金属的系统的毒性或复杂配体的问题。使用手性乳酸基高价碘试剂，将烯烃与 N-磺酰脲进行高度对映选择性的氧胺化，首次轻松合成对映体纯的 2-芳基脯氨酸衍生物。
The ring and I: hypervalent iodine compounds avoid the issues of toxicity or complicated ligands of many transition-metal-based systems. A highly enantioselective oxyamination of alkenes with N-sulfonyl ureas employing chiral, lactic acid-based hypervalent iodine reagents gives a facile synthesis of enantiomerically pure 2-arylproline derivatives for the first time.