Evolution of Shc functions from nematode to human
Evolution of Shc functions from nematode to human
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DOI：
10.1016/s0959-437x(00)00146-5
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发表时间：
2000-12-01
影响因子：
4
通讯作者：
Pelicci, PG
中科院分区：
文献类型：
--
作者：
Luzi, L;Confalonieri, S;Pelicci, PG
Shc蛋白家族的特征在于（CHP）-PTB-CH 1-SH 2模块性。其复杂性在进化过程中从果蝇的一个位点（dShc）增加到哺乳动物的至少三个位点（shc，rai和sri）。这三个哺乳动物基因座编码，由于选择性的起始密码子使用和剪接模式，至少六个她样蛋白。遗传和生物学证据表明，哺乳动物Shc亚型调节多种功能，如生长（p52/p46 Shc）、凋亡（p66 Shc）和寿命（p66 Shc）。现有的结构-功能数据和分析的序列相似性的She样基因和蛋白质表明复杂的多样化的Shc功能在进化过程中。值得注意的是，Ras激活，最具特征的Shc活动，似乎是一个最近的进化收购。
The Shc protein family is characterized by the (CHP)-PTB-CH1 -SH2 modularity. Its complexity increased during evolution from one locus in Drosophila (dShc), to at least three loci in mammals (shc, rai and sri). The three mammalian loci encode, because of alternative initiation codon usage and splicing pattern, at least six She-like proteins. Genetic and biological evidence indicates that the mammalian Shc isoforms regulate functions as diverse as growth (p52/p46Shc), apoptosis (p66Shc) and life-span (p66Shc). Available structure-function data and analysis of sequence similarities of She-like genes and proteins suggest complex diversification of Shc functions during evolution. Notably, Ras activation, the best-characterized Shc activity, appears to be a recent evolutionary acquisition.