Integrated optical devices for lab-on-a-chip biosensing applications
Integrated optical devices for lab-on-a-chip biosensing applications
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DOI：
10.1002/lpor.201100025
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发表时间：
2012-07-01
影响因子：
11
通讯作者：
Lechuga, Laura M.
中科院分区：
文献类型：
--
作者：
Estevez, M-Carmen;Alvarez, Mar;Lechuga, Laura M.
应用便携式、易用和高灵敏度的芯片上实验室生物传感设备进行实时诊断可以提供比现有分析方法更大的优势。基于集成光学的生物传感器因其小型化能力、极高的灵敏度、稳健性和可靠性，以及以低成本进行多路复用和大规模生产的潜力，已成为最适合芯片实验室集成的技术。本文综述了集成光子生物传感器技术的最新进展，包括干涉仪、光栅耦合器、微环谐振器、光子晶体和其他新型的纳米光子换能器。特别强调描述它们的实际生物传感应用，并尽可能包括每种类型设备之间的传感性能的比较。此外，还对如何实现集成光子生物传感器的芯片实验室平台进行了综述。还提供了关于这项技术的未来前景和潜在影响的结束语。
The application of portable, easy-to-use and highly sensitive lab-on-a-chip biosensing devices for real-time diagnosis could offer significant advantages over current analytical methods. Integrated optics-based biosensors have become the most suitable technology for lab-on-chip integration due to their ability for miniaturization, their extreme sensitivity, robustness, reliability, and their potential for multiplexing and mass production at low cost. This review provides an extended overview of the state-of-the-art in integrated photonic biosensors technology including interferometers, grating couplers, microring resonators, photonic crystals and other novel nanophotonic transducers. Particular emphasis has been placed on describing their real biosensing applications and wherever possible a comparison of the sensing performances between each type of device is included. The way towards achieving operative lab-on-a-chip platform incorporating the photonic biosensors is also reviewed. Concluding remarks regarding the future prospects and potential impact of this technology are also provided.