Branch-based model for the diameters of the pulmonary airways: accounting for departures from self-consistency and registration errors.
Branch-based model for the diameters of the pulmonary airways: accounting for departures from self-consistency and registration errors.
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基于分支的肺气道直径模型：考虑自一致性的偏差和配准错误。
DOI：
10.1002/ar.22476
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Corley,RichardA
中科院分区：
文献类型：
--
作者：
Neradilek,MoniB;Polissar,NayakL;Einstein,DanielR;Glenny,RobbW;Minard,KevinR;Carson,JamesP;Jiao,Xiangmin;Jacob,RichardE;Cox,TimothyC;Postlethwait,EdwardM;Corley,RichardA
We examine a previously published branch‐based approach for modeling airway diameters that is predicated on the assumption of self‐consistency across all levels of the tree. We mathematically formulate this assumption, propose a method to test it and develop a more general model to be used when the assumption is violated. We discuss the effect of measurement error on the estimated models and propose methods that take account of error. The methods are illustrated on data from MRI and CT images of silicone casts of two rats, two normal monkeys, and one ozone‐exposed monkey. Our results showed substantial departures from self‐consistency in all five subjects. When departures from self‐consistency exist, we do not recommend using the self‐consistency model, even as an approximation, as we have shown that it may likely lead to an incorrect representation of the diameter geometry. The new variance model can be used instead. Measurement error has an important impact on the estimated morphometry models and needs to be addressed in the analysis. Anat Rec,, 2012. © 2012 Wiley Periodicals, Inc.
