Spleen size and chromosome analysis as prognostic factors in chronic myelogenous leukemia.
Spleen size and chromosome analysis as prognostic factors in chronic myelogenous leukemia.
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脾脏大小和染色体分析作为慢性粒细胞白血病的预后因素。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
Meydrech Ef
中科院分区：
文献类型：
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作者：
Collins Rk;Jackson Jf;Morrison Fs;Meydrech Ef
在72例慢性粒细胞白血病（CML）患者中，37例Ph 1阳性，8例阴性，27例未进行Ph 1染色体评估。在37例Ph1阳性患者中，31例接受了充分评价。根据脾脏大小对这31例患者的生存率进行了审查。17例脾脏位于左肋缘下3 cm或以下的患者，50%生存75个月，平均生存53.9个月。14例脾脏位于左肋缘下大于3 cm的患者的50%生存期为21个月，平均生存期为19个月（P = 0.0014）。结论：CML患者脾脏小与生存期延长有关。这可能是这一观察应考虑到当考虑脾切除术在管理慢性粒细胞白血病患者。
: Of 72 patients with chronic myelogenous leukemia (CML), 37 were Ph1 positive, eight were negative, and 27 were not evaluated for the Ph1 chromosome. Of the 37 patients positive for Ph1, 31 had adequate evaluation. These 31 patients were reviewed for survival with reference to spleen size. Seventeen patients with spleens 3 cm or less below the left costal margin had a 50% survival of 75 months, with a mean survival of 53.9 months. Fourteen patients with spleens greater than 3 cm below the left costal margin had a 50% survival of 21 months, with a mean survival of 19 months (P = .0014). It is concluded that small splenic size in CML is associated with longer survival. It may be that this observation should be taken into consideration when considering splenectomy in the management of patients with CML.