Required transition from research to clinical application: Report on the 4D treatment planning workshops 2014 and 2015
Required transition from research to clinical application: Report on the 4D treatment planning workshops 2014 and 2015
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DOI：
10.1016/j.ejmp.2016.05.064
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发表时间：
2016-07-01
影响因子：
3.4
通讯作者：
McClelland, Jamie
中科院分区：
文献类型：
--
作者：
Knopf, Antje-Christin;Stuetzer, Kristin;McClelland, Jamie
自2009年以来，每年举办一次4D治疗计划研讨会，聚集研究移动目标治疗的研究人员，主要是使用扫描离子束。研讨会期间讨论的主题包括时间分辨成像的问题、运动建模的挑战、治疗计划中4D功能的实现，以及与4D剂量测定和治疗验证相关的不同方面。本报告概述了2014年和2015年4D研讨会上讨论的主题。报告总结了该领域的最新研究结果、发展和挑战，并讨论了近年来的相关文献。该报告分为三个部分，指出了在理解移动几何形状，治疗移动目标和4D质量保证（QA）和4D剂量学方面的发展。在4D研讨会上代表的社区一致认为，在用扫描离子束治疗移动目标的背景下，研究面临着临床翻译的关键阶段。在未来的几年里，重要的是要定义运动监测的标准，建立4D治疗计划指南和开发4D QA工具。ESTRO的一个专门工作组可以确定扫描离子束在移动目标中的临床应用的基本要求。除了回顾最近的研究成果并指出扫描离子束治疗移动目标的迫切需求外，报告还对即将于2016年底在荷兰格罗宁根大学医学中心（UMCG）举办的4D研讨会进行了展望。(C)2016年意大利医学协会。由爱思唯尔有限公司出版。保留所有权利。
Since 2009, a 4D treatment planning workshop has taken place annually, gathering researchers working on the treatment of moving targets, mainly with scanned ion beams. Topics discussed during the workshops range from problems of time resolved imaging, the challenges of motion modelling, the implementation of 4D capabilities for treatment planning, up to different aspects related to 4D dosimetry and treatment verification.This report gives an overview on topics discussed at the 4D workshops in 2014 and 2015. It summarizes recent findings, developments and challenges in the field and discusses the relevant literature of the recent years. The report is structured in three parts pointing out developments in the context of understanding moving geometries, of treating moving targets and of 4D quality assurance (QA) and 4D dosimetry.The community represented at the 4D workshops agrees that research in the context of treating moving targets with scanned ion beams faces a crucial phase of clinical translation. In the coming years it will be important to define standards for motion monitoring, to establish 4D treatment planning guidelines and to develop 4D QA tools. These basic requirements for the clinical application of scanned ion beams to moving targets could e.g. be determined by a dedicated ESTRO task group.Besides reviewing recent research results and pointing out urgent needs when treating moving targets with scanned ion beams, the report also gives an outlook on the upcoming 4D workshop organized at the University Medical Center Groningen (UMCG) in the Netherlands at the end of 2016. (C) 2016 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.