Detection of Group A Streptococcus in Pharyngeal Swab Specimens by Use of the AmpliVue GAS Isothermal Helicase-Dependent Amplification Assay
Detection of Group A Streptococcus in Pharyngeal Swab Specimens by Use of the AmpliVue GAS Isothermal Helicase-Dependent Amplification Assay
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DOI：
10.1128/jcm.01085-15
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发表时间：
2015-07-01
影响因子：
9.4
通讯作者：
Buchan, Blake W.
中科院分区：
文献类型：
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作者：
Faron, Matthew L.;Ledeboer, Nathan A.;Buchan, Blake W.
我们使用1，192份咽拭子样本评价了AmpliVue A组链球菌（GAS）等温解旋酶依赖性扩增检测试剂盒的临床性能（灵敏度和特异性）。将AmpliVue GAS检测结果与选择性链球菌血琼脂平板上的常规咽喉培养结果进行比较。AmpliVue GAS检测试剂盒的灵敏度和特异性分别为98.3%（95%置信区间[CI]，95 - 100%）和93.2%（95% CI，91 - 95%）。
We evaluated the clinical performance (sensitivity and specificity) of the AmpliVue group A Streptococcus (GAS) isothermal helicase-dependent amplification assay using 1,192 pharyngeal swab specimens. AmpliVue GAS assay results were compared to the results of routine throat cultures on selective streptococcal blood agar plates. The sensitivity and specificity of the AmpliVue GAS assay were 98.3% (95% confidence interval [CI], 95 to 100%) and 93.2% (95% CI, 91 to 95%), respectively.