Nitrous oxide-induced hypothermia in the rat.
Nitrous oxide-induced hypothermia in the rat.
复制标题
一氧化二氮引起的大鼠体温过低。
DOI：
10.1016/0024-3205(87)90447-4
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发表时间：
1987
期刊：
影响因子：
6.1
通讯作者：
Rosenthal,MA
中科院分区：
文献类型：
--
作者：
Quock,RM;Panek,RW;Kouchich,FJ;Rosenthal,MA
大鼠暴露于高浓度的一氧化二氮（N2 O）的氧气（O2）中，以浓度相关的方式降低体温。纳洛酮预处理可部分逆转低温，但纳洛酮不能逆转低温。但是，在大鼠耐受吗啡丸植入，暴露于75%N2O/25%O2诱发了显着的体温下降，在吗啡的幼稚动物中观察到的相似。在另一项实验中，水合氯醛的降温作用也对纳洛酮预处理的拮抗作用敏感，但对纳洛酮不敏感。这些观察结果使我们怀疑N2 O诱导的大鼠体温降低可能不是由阿片受体介导的。N2 O的向热活性可能是由N2 O的某些非阿片作用引起的.纳洛酮（而不是纳洛酮）的选择性拮抗作用可能是由于纳洛酮独特的非阿片类兴奋剂作用。
Exposure of rats to high levels of nitrous oxide (N 2 O) in oxygen (O 2) reduced body temperature in a concentration-related manner. The hypothermia was partly reversed by pretreatment with naloxone but not naltrexone. But in rats rendered tolerant to morphine by pellet implantation, exposure to 75% N 2 O/25% O 2 evoked a marked hypothermia similar to that observed in morphine-naive animals. In another experiment, the hypothermic effect of chloral hydrate was also sensitive to antagonism by pretreatment with naloxone but not naltrexone. These observations lead us to suspect that N 2 O-induced hypothermia in rats is possibly not mediated by opiate receptors. The thermotropic activity of N 2 O may result from some non-opioid action of N 2 O. Its selective antagonism by naloxone (but not naltrexone) may be due to a unique non-opioid analeptic action of naloxone.