Effect of 1-year smoking cessation on airway inflammation in COPD and asymptomatic smokers
Effect of 1-year smoking cessation on airway inflammation in COPD and asymptomatic smokers
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DOI：
10.1183/09031936.05.00108904
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发表时间：
2005-11-01
影响因子：
24.3
通讯作者：
Timens, W
中科院分区：
文献类型：
--
作者：
Willemse, BWM;ten Hacken, NHT;Timens, W
戒烟是慢性阻塞性肺疾病（COPD）患者中唯一有效减缓疾病进展的治疗方法。为了阐明戒烟对气道炎症的影响，28例COPD吸烟者，（平均年龄：55岁;一秒钟用力呼气量：71%的预测值）和25名无症状吸烟者与正常肺功能（年龄50岁）被纳入一个为期1年的戒烟计划。在支气管活检中研究戒烟对气道炎症的影响（基线，12个月）和痰液样本在12名成功戒烟的COPD候选人中，气道炎症在支气管活检中持续存在，而痰中性粒细胞，淋巴细胞，白细胞介素（IL）-8和嗜酸性粒细胞阳离子蛋白水平在12个月时显著升高。在16名成功戒烟的无症状吸烟者中，炎症显著减少（即痰巨噬细胞数量，嗜酸性粒细胞百分比和IL-8水平）或没有改变。目前的作者认为，慢性阻塞性肺疾病患者中观察到的持续气道炎症与气道组织损伤的修复有关。这是否反映了有益或有害的影响仍有待阐明。
Smoking cessation is the only treatment in patients with chronic obstructive pulmonary disease (COPD) effective in slowing down disease progression. Its effect on airway inflammation in COPD is unknown, although cross-sectional studies suggest ongoing inflammation in ex-smokers.In order to elucidate the effect of smoking cessation on airway inflammation, 28 smokers with COPD (mean age: 55 yrs; forced expiratory volume in one second: 71% predicted) and 25 asymptomatic smokers with normal lung function (aged 50 yrs) were included in a 1-yr smoking cessation programme. Effects of smoking cessation on airway inflammation were investigated in bronchial biopsies (baseline, 12 months) and sputum samples (baseline, 2, 6 and 12 months).In the 12 candidates with COPD who successfully ceased smoking, airway inflammation persisted in bronchial biopsies, while the number of sputum neutrophils, lymphocytes, interleukin (IL)-8 and eosinophilic-cationic-protein levels significantly increased at 12 months. In the 16 asymptomatic smokers who successfully quitted, inflammation significantly reduced (i.e. number of sputum macrophages, percentage of eosinophils and IL-8 levels) or did not change.The current authors suggest that the observed persistent airway inflammation in patients with chronic obstructive pulmonary disease is related to repair of tissue damage in the airways. It remains to be elucidated whether this reflects a beneficial or detrimental effect.