Occurrence of autoantibodies to human leucocyte elastase in Wegener's granulomatosis and other inflammatory disorders.
Occurrence of autoantibodies to human leucocyte elastase in Wegener's granulomatosis and other inflammatory disorders.
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韦格纳肉芽肿病和其他炎症性疾病中出现针对人白细胞弹性蛋白酶的自身抗体。
DOI：
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发表时间：
1993
影响因子：
27.4
通讯作者：
C. Kallenberg
中科院分区：
文献类型：
--
作者：
J. Tervaert;L. Mulder;C. Stegeman;J. D. Elema;M. Huitema;C. Kallenberg
抗神经细胞胞浆抗体（ANCA）是一类新的自身抗体，似乎可以识别髓样溶酶体酶。在常规提交用于ANCA测定的血清样本中评估了对人白细胞弹性蛋白酶（HLE）具有特异性的ANCA的发生率。在一项为期6年多的研究中，1102份血清样本中只有6份发现了抗HLE，这些样本在乙醇固定的粒细胞上产生核周或非典型胞质染色模式。这6份血清样本来自4名临床诊断为韦格纳肉芽肿但没有明确组织学诊断的患者，1名系统性血管炎患者和1名Cogan综合征患者。为了进一步评估抗HLE的患病率，我们检测了315份来自不同形式血管炎和相关疾病患者的血清样本。仅在2例患者中检测到抗HLE。因此，在血管炎或相关疾病患者的血清样本中很少发现HLE自身抗体。
Antineutrophil cytoplasmic antibodies (ANCAs) constitute a new class of autoantibodies that seem to recognise myeloid lysosomal enzymes. The occurrence of ANCAs with specificity for human leucocyte elastase (HLE) was assessed in serum samples that were routinely submitted for ANCA determination. During a study period of more than six years anti-HLE was found in only six out of 1102 serum samples that produced a perinuclear or an atypical cytoplasmic staining pattern on ethanol fixed granulocytes. These six serum samples were from four patients with a clinical diagnosis of Wegener's granulomatosis but without a definite histological diagnosis, one patient with systemic vasculitis, and one patient with Cogan's syndrome. To further evaluate the prevalence of anti-HLE we tested 315 serum samples from patients with different forms of vasculitis and related disorders. Anti-HLE was detected in two patients only. Thus autoantibodies to HLE are rarely found in serum samples from patients with vasculitic or related disorders.
中性粒细胞胞浆抗体：原发性硬化性胆管炎和溃疡性结肠炎之间的联系。
影响因子：
29.4
作者：
Duerr,RH;Targan,SR;Landers,CJ;LaRusso,NF;Lindsay,KL;Wiesner,RH;Shanahan,F
通讯作者：
Shanahan,F
影响因子：
158.5
作者：
FALK, RJ;JENNETTE, JC
通讯作者：
JENNETTE, JC
影响因子：
20.3
作者：
J. Niles;R. McCluskey;MF Ahmad;M. Arnaout
通讯作者：
J. Niles;R. McCluskey;MF Ahmad;M. Arnaout