Successful Case of Periodontal Tissue Repair With Fibroblast Growth Factor-2: Long-Term Follow-Up and Comparison to Enamel Matrix Derivative
Successful Case of Periodontal Tissue Repair With Fibroblast Growth Factor-2: Long-Term Follow-Up and Comparison to Enamel Matrix Derivative
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DOI：
10.1902/cap.2012.120014
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发表时间：
2013-11-01
影响因子：
0.7
通讯作者：
Nagata, Toshihiko
中科院分区：
文献类型：
--
作者：
Ninomiya, Masami;Azuma, Tomoko;Nagata, Toshihiko
简介：碱性成纤维细胞生长因子-2（FGF-2）是一种促进牙周组织再生的因子，对牙周炎患者牙槽骨缺损有效。虽然已经报道了用FGF-2治疗的病例，但据我们所知，没有关于FGF-2治疗病例的长期观察的信息。在这种情况下，报告中，一个成功的情况下，治疗FGF-2超过9年的后续描述和比较的情况下，治疗与釉基质衍生物（EMD）在同一patient.Case介绍：2001年至2004年进行了2A期临床试验的FGF-2应用牙周再生治疗。选择了一名52岁的女性患者，患有牙周炎，牙齿#3和#14处有对称性骨缺损。当进行皮瓣手术时，将FGF-2（牙齿#3）和EMD（牙齿#14）应用于在近中部位进展的垂直骨缺损。临床附着增量和骨高度在部位#3呈时间依赖性增加。在36周时直接观察部位#3的牙槽骨，证实了近中骨缺损和分叉病变的恢复。当比较两个部位之间的临床参数时，3号部位的附着增加和骨恢复率大于14号部位。这些条件已经维持了9 years.Conclusion：本病例报告显示，局部应用FGF-2诱导显著的牙周组织修复在垂直骨缺损和分叉病变的上第一磨牙，这一直保持良好的9年。
Introduction: Basic fibroblast growth factor-2 (FGF-2) is a stimulatory agent for periodontal tissue regeneration and is efficacious on alveolar bone defects in periodontitis patients. Although cases treated with FGF-2 have been reported, to the best of our knowledge, there is no information concerning long-term observation of FGF-2-treated cases. In this case report, a successful case treated with FGF-2 over 9 years of follow-up is described and compared to a case treated with enamel matrix derivative (EMD) in the same patient.Case Presentation: A phase 2A clinical trial of FGF-2 application for periodontal regeneration therapy was conducted from 2001 to 2004. A 52-year-old female patient with periodontitis and symmetric bone defects at teeth #3 and #14 was selected. When flap surgery was performed, FGF-2 (tooth #3) and EMD (tooth #14) were applied to the vertical bone defects that had progressed in the mesial sites. Clinical attachment gain and bone height time-dependently increased at site #3. Direct observation of alveolar bone of site #3 at 36 weeks demonstrated recovery of mesial bone defect and furcation lesion. When the clinical parameters were compared between the sites, attachment gain and bone recovery rate were greater in site #3 than in site #14. These conditions have been maintained for 9 years.Conclusion: The present case report shows that topical application of FGF-2 induced marked periodontal tissue repair in a vertical bone defect and a furcation lesion of the upper first molar, which has been well maintained for 9 years.