T cell subsets and their signature cytokines in autoimmune and inflammatory diseases.
T cell subsets and their signature cytokines in autoimmune and inflammatory diseases.
复制标题
DOI：
10.1016/j.cyto.2014.09.011
复制
发表时间：
2015-07
期刊：
影响因子：
3.8
通讯作者：
Forsthuber, Thomas G.
中科院分区：
文献类型：
--
作者：
Raphael, Itay;Nalawade, Saisha;Eagar, Todd N.;Forsthuber, Thomas G.
关键词：
CD4+T辅助细胞(Th)对免疫细胞稳态和宿主防御至关重要，但也是自身免疫性疾病和炎症性疾病的主要致病因素。自从Th1/Th2二分法被发现以来，许多额外的Th亚群被发现，每个亚群都有独特的细胞因子谱、功能特性和在自身免疫组织病理中的假定作用。这包括Th1、Th2、Th17、Th22、Th9和Treg细胞，它们具有特定的细胞因子谱。由这些Th亚群产生的细胞因子在免疫细胞分化、效应器亚群承诺和指导效应器反应中起着关键作用。细胞因子通常分为促炎细胞因子和抗炎细胞因子，并与表达它们的Th亚群相关联。本文综述了不同的Th亚群的细胞因子谱，这些细胞因子如何影响和塑造免疫反应，以及它们在自身免疫性和炎症性疾病中促进病理的相关作用。此外，我们将讨论是否可以仅根据Th细胞的细胞因子谱来定义Th细胞的致病性，以及根据其细胞因子谱严格定义Th细胞亚群是否有帮助。
CD4+T helper (Th) cells are critical for proper immune cell homeostasis and host defense, but are also major contributors to pathology of autoimmune and inflammatory diseases. Since the discovery of the Th1/Th2 dichotomy, many additional Th subsets were discovered, each with a unique cytokine profile, functional properties, and presumed role in autoimmune tissue pathology. This includes Th1, Th2, Th17, Th22, Th9, and Treg cells which are characterized by specific cytokine profiles. Cytokines produced by these Th subsets play a critical role in immune cell differentiation, effector subset commitment, and in directing the effector response. Cytokines are often categorized into proinflammatory and anti-inflammatory cytokines and linked to Th subsets expressing them. This article reviews the different Th subsets in terms of cytokine profiles, how these cytokines influence and shape the immune response, and their relative roles in promoting pathology in autoimmune and inflammatory diseases. Furthermore, we will discuss whether Th cell pathogenicity can be defined solely based on their cytokine profiles and whether rigid definition of a Th cell subset by its cytokine profile is helpful.
登录
查看更多内容
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
3.8
作者：
Cai, LP;Yin, JP;Filvaroff, EH
通讯作者：
Filvaroff, EH
DOI：
10.1191/135245801680209303
发表时间：
2001-08-01
期刊：
MULTIPLE SCLEROSIS
影响因子：
--
作者：
Chen, M;Gran, B;Dhib-Jalbut, S
通讯作者：
Dhib-Jalbut, S
白介素10在抑制肠炎的调节T细胞功能中的重要作用。
影响因子：
15.3
作者：
Asseman, C;Mauze, S;Leach, M W;Coffman, R L;Powrie, F
通讯作者：
Powrie, F
影响因子：
6
作者：
Afanasyeva, M;Wang, Y;Rose, NR
通讯作者：
Rose, NR