Adaptation in the corticosterone and hyperthermic responses to stress following repeated stressor exposure
Adaptation in the corticosterone and hyperthermic responses to stress following repeated stressor exposure
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DOI：
10.1111/j.1365-2826.2007.01571.x
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发表时间：
2007-08-01
影响因子：
3.2
通讯作者：
Deak, T.
中科院分区：
文献类型：
--
作者：
Barnum, C. J.;Blandino, P., Jr.;Deak, T.
先前的研究表明，每天重复暴露于相同的(同型)应激源会导致皮质酮(CORT)反应的习惯性。其他人发现，对与行为更相关的压力源--社会失败--的压力反应并不习惯，在某些情况下，已经观察到了敏感化。当检查核心温度时，也注意到了类似的观察结果。虽然在应激源暴露期间已有习惯性和/或敏感化的报道，但对日常应激源暴露引起的预见性发热的发展情况知之甚少。本研究的目的是使用一套通用的程序和分析，系统地比较常用的实验室应激源(即约束、笼子限制和社会失败)。具体地说，我们检查了：(I)预期发烧到重复(5天)同型应激源暴露；(Ii)在应激源暴露期间发热反应的适应；以及(Iii)对每天同一时间呈现的应激源的发热反应的解决。为了进行比较，还检查了CORT反应的适应性，以评估对重复应激源暴露的习惯性程度可能代表在不同生理指标中观察到的更一般的反应。在束缚和笼子禁闭后观察到习惯化，但在CORT或对重复的社会失败的高热反应中都没有观察到。此外，在反复暴露于束缚、笼子限制或社会失败的情况下，没有观察到预期的发热反应。这些数据表明，对重复应激源暴露的习惯性可能并不是所有同型应激源范例都会发生。此外，老鼠似乎不会对每天同一时间出现的应激源产生预期的发热反应，至少在重复暴露的5-6天内不会。
Previous studies have shown that repeated daily exposure to the same (homotypic) stressor results in habituation of the corticosterone (CORT) response. Others have found that the stress response to a more ethologically relevant stressor, social defeat, does not habituate and, in some cases, sensitisation has been observed. Similar observations have been noted when core temperature is examined. Although habituation and/or sensitisation have been reported during stressor exposure, little is known about the development of an anticipatory fever in response to daily stressor exposure. The aim of the present study was to compare systematically commonly used laboratory stressors (i.e. restraint, cage confinement and social defeat) using a common set of procedures and analyses. Specifically, we examined: (i) the development of an anticipatory fever to repeated (5 days) homotypic stressor exposure; (ii) the adaptation of the fever response during stressor exposure; and (iii) the resolution of the fever response to stressors presented at the same time each day. For comparison, adaptation of the CORT response was also examined to assess the degree to which habituation to repeated stressor exposure may represent a more general response observed across diverse physiological measures. Habituation was observed after restraint and cage confinement, but not observed in either the CORT or hyperthermic responses to repeated social defeat. Furthermore, no anticipatory fever response was observed with repeated exposure to restraint, cage confinement, or social defeat. These data suggest that habituation to repeated stressor exposure may not occur with all homotypic stressor paradigms. In addition, rats do not appear to entrain an anticipatory fever response to a stressor presented at the same time each day, at least not within 5-6 days of repeated exposure.