Cholinergic regulation of ghrelin and peptide YY release may be impaired in obesity
Cholinergic regulation of ghrelin and peptide YY release may be impaired in obesity
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DOI：
10.2337/db07-0758
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发表时间：
2008-09-01
期刊：
影响因子：
7.7
通讯作者：
Luger, Anton
中科院分区：
文献类型：
--
作者：
Maier, Christina;Riedl, Michaela;Luger, Anton
目的-Ghrelin 和肽 YY (PYY) 都是来自胃肠道的激素，参与食欲调节。迷走神经的胆碱能部分参与葡萄糖和胰岛素的调节。本研究的目的是检查胆碱能拮抗剂阿托品在基础条件下和餐后摄入对瘦和肥胖受试者中胃饥饿素、PYY、葡萄糖和胰岛素的影响。 研究设计和方法 - 八名瘦中八肥胖受试者被纳入一项随机、双盲、安慰剂对照交叉研究，按随机顺序进行 4 个研究日（阿托品/安慰剂 +/- 早餐）。测量血浆生长素释放肽、PYY、胰岛素和葡萄糖。饥饿感和饱腹感以 10 厘米视觉模拟量表进行评分。 结果：在瘦人中，阿托品导致胃饥饿素浓度降低，与早餐摄入相当且无累加性，并且基础和膳食诱导的 PYY 浓度显着降低。在肥胖受试者中，阿托品没有显着改变生长素释放肽或 PYY 浓度，但它在两个研究组中引起心率和膳食引起的葡萄糖浓度相当的增加。只有瘦的受试者在早餐后才会有持续的饱腹感，而不是肥胖的受试者。结论：餐后胃饥饿素浓度下降和 PYY 浓度上升的胆碱能调节受损可能是肥胖受试者食物摄入失调的一部分。
OBJECTIVE-Ghrelin and peptide YY (PYY) are both hormones derived from the gastrointestinal tract involved in appetite regulation. The cholinergic part of the vagal nerve is involved in the regulation of glucose and insulin. The aim of this study was to examine the effects of the cholinergic antagonist atropine off ghrelin, PYY, glucose, and insulin under basal conditions and after meal ingestion in lean and obese subjects.REASEARCH DESIGN AND METHODS-Eight lean mid eight obese subjects were included in a randomized, double-blind, placebo-controlled crossover study with 4 study days in randomized order (atropine/placebo +/- breakfast). Plasma ghrelin, PYY, insulin, and glucose were measured. Hunger and satiety feelings were rated on a 10-cm visual analog scale.RESULTS-In lean individuals, atropine led to a decrease in ghrelin concentrations comparable and nonadditive with breakfast ingestion and a significant decrease in both basal and meal-induced PYY concentrations. In obese subjects, atropine did not significantly change ghrelin or PYY concentrations, whereas it induced a comparable increase in heart rate and meal-induced glucose concentrations in the two study groups. Only lean, not obese, Subjects experienced sustained feelings of satiety after breakfast.CONCLUSIONS-The impaired cholinergic regulation of the postprandial drop in ghrelin concentrations and rise in PYY concentrations might be part of the deregulated food intake in obese subjects.