Characterization of antibodies induced by vaccination with hepatitis C virus envelope glycoproteins.
Characterization of antibodies induced by vaccination with hepatitis C virus envelope glycoproteins.
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DOI：
10.1086/655902
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发表时间：
2010-09-15
期刊：
影响因子：
--
通讯作者：
Belshe RB
中科院分区：
文献类型：
--
作者：
Ray R;Meyer K;Banerjee A;Basu A;Coates S;Abrignani S;Houghton M;Frey SE;Belshe RB
Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 were used with MF59 adjuvant as a candidate vaccine for a phase 1 safety and immunogenicity trial. Ten of 41 vaccinee serum samples displayed a neutralization titer of ⩾1:20 against vesicular stomatitis virus (VSV)-HCV pseudotype, 15 of 36 serum samples tested had a neutralization titer of ⩾1:400 against human immunodeficiency virus (HIV)-HCV pseudotype, and 10 of 36 serum samples tested had a neutralization titer of ⩾1:20 against cell culture-grown HCV genotype 1a. Neutralizing serum samples had increased affinity levels and displayed >2-fold higher specific activity levels to well-characterized epitopes on E1/E2, especially to the hypervariable region 1 of E2.
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影响因子：
5.4
作者：
Kanda, T;Basu, A;Ray, RB
通讯作者：
Ray, RB
DOI：
10.1073/pnas.89.8.3468
发表时间：
1992-04-15
影响因子：
11.1
作者：
WEINER, AJ;GEYSEN, HM;HOUGHTON, M
通讯作者：
HOUGHTON, M
影响因子：
5.4
作者：
RAY, R;KHANNA, A;BECHERER, PR
通讯作者：
BECHERER, PR
影响因子：
6.4
作者：
Lagging, LM;Meyer, K;Ray, R
通讯作者：
Ray, R
影响因子：
13.5
作者：
Rothman, AL;Morishima, C;Koziel, MJ
通讯作者：
Koziel, MJ