Dysfunctional HDL and progression of atherosclerosis in HIV-1-infected and -uninfected adults
Dysfunctional HDL and progression of atherosclerosis in HIV-1-infected and -uninfected adults
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DOI：
10.1186/1476-511x-12-23
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发表时间：
2013-03-05
影响因子：
4.5
通讯作者：
Currier, Judith S.
中科院分区：
文献类型：
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作者：
Kelesidis, Theodoros;Yang, Otto O.;Currier, Judith S.
背景：HDL功能而不是绝对水平可能是一个更准确的动脉粥样硬化风险指标。功能失调的HDL增加了氧化还原活性，降低了抗氧化性能，但目前尚不清楚HDL功能异常是否与hiv -1感染受试者动脉粥样硬化的进展有关。研究结果：我们回顾性地测量了91名受试者的血清HDL功能，这些受试者来自一项为期3年的颈动脉内膜-中膜厚度（CIMT）的前瞻性研究，该研究纳入了三组危险因素匹配的患者，这些患者未感染HIV-1 （n=36）或HIV-1+ (n=29)或未（n=26）以蛋白酶抑制剂（PI）为基础治疗>= 2年。通过测量二氢何旦胺123的氧化（DHR氧化率，DOR）的生化测定来评估HDL功能，其中较高的DOR读数对应于功能失调的HDL表型。DOR和HIV-1感染之间没有明显的关联。在55名hiv -1感染者的单因素分析中，腰围越大、血清HDL越低与DOR基线水平越高显著相关（p=0.01）。随着时间的推移（3年），这些受试者的DOR水平显著增加，与白种人有关（p=0.03）， CD4最低计数较高（p=0.03）
Background: HDL function rather than absolute level may be a more accurate indicator for risk of developing atherosclerosis. Dysfunctional HDL has increased redox activity and reduced antioxidant properties, but it is unknown whether abnormal HDL function is associated with progression of atherosclerosis in HIV-1-infected subjects.Findings: We retrospectively measured serum HDL function in 91 subjects from a prospective 3-year study of carotid artery intima-media thickness (CIMT), which enrolled triads of risk factor-matched persons that were HIV-1-uninfected (n=36) or HIV-1+ with (n=29) or without (n=26) protease inhibitor (PI)-based therapy for >= 2 years. HDL function was assessed using a biochemical assay that measures the oxidation of dihydrorhodamine 123 (DHR oxidation rate, DOR), in which higher DOR readout corresponds to dysfunctional HDL phenotype. There were no significant associations between DOR and HIV-1 infection. In univariate analysis of 55 HIV-1-infected subjects, greater waist circumference and lower serum HDL were significantly associated with higher baseline levels of DOR (p=0.01). These subjects had significant increases in levels of DOR over time (3 years) that were associated with white race (p=0.03), higher nadir CD4 count (p