Neuroprotective effects of vitexin by inhibition of NMDA receptors in primary cultures of mouse cerebral cortical neurons
Neuroprotective effects of vitexin by inhibition of NMDA receptors in primary cultures of mouse cerebral cortical neurons
复制标题
牡荆素通过抑制小鼠大脑皮层神经元原代培养物中 NMDA 受体的神经保护作用
DOI：
10.1007/s11010-013-1862-9
复制
发表时间：
2013
影响因子：
4.3
通讯作者：
M.G.Zhao
中科院分区：
文献类型：
--
作者：
N. Zhang;Z. Tian;S.B. Liu;M.G.Zhao
The accumulation of glutamate can excessively activate theN-methyl-d-aspartate (NMDA) receptors and cause excitotoxicity. Vitexin (5, 7, 4-trihydroxyflavone-8-glucoside, Vit) is a c-glycosylated flavone which was found in the several herbs, exhibiting potent hypotensive, anti-inflammatory, and neuroprotective properties. However, little is known about the neuroprotective effects of Vit on glutamate-induced excitotoxicity. In present study, primary cultured cortical neurons were treated with NMDA to induce the excitotoxicity. Pretreatment with Vit significantly prevented NMDA-induced neuronal cell loss and reduced the number of apoptotic neurons. Vit significantly inhibited the neuronal apoptosis induced by NMDA exposure by regulating balance of Bcl-2 and Bax expression and the cleavages of poly (ADP-ribose) polymerase and pro-caspase 3. Furthermore, pretreatment of Vit reversed the up-regulation of NR2B-containing NMDA receptors and the intracellular Ca2+overload induced by NMDA exposure. The neuroprotective effects of Vit are related to inhibiting the activities of NR2B-containing NMDA receptors and reducing the calcium influx in cultured cortical neurons.
登录
查看更多内容
影响因子：
4.7
作者：
Wu Y;Peng H;Cui M;Whitney NP;Huang Y;Zheng JC
通讯作者：
Zheng JC
DOI：
10.1073/pnas.0903546106
发表时间：
2009-06-16
影响因子：
11.1
作者：
Stanika, Ruslan I.;Pivovarova, Natalia B.;Andrews, S. Brian
通讯作者：
Andrews, S. Brian
影响因子：
3.3
作者：
Vander Jagt TA;Connor JA;Weiss JH;Shuttleworth CW
通讯作者：
Shuttleworth CW
影响因子：
5.3
作者：
Liu, Yitao;Wong, Tak Pan;Wang, Yu Tian
通讯作者：
Wang, Yu Tian
影响因子：
5.8
作者：
GAITAN, E;LINDSAY, RH;KUBOTA, K
通讯作者：
KUBOTA, K