Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis
Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis
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DOI：
10.1038/ncb856
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发表时间：
2002-10-01
影响因子：
21.3
通讯作者：
Payre, F
中科院分区：
文献类型：
--
作者：
Polesello, C;Delon, I;Payre, F
Ezrin、Radixin和Moesin（ERM）蛋白被认为构成肌动蛋白细胞骨架和质膜（PM）之间的桥梁。在这里，我们报告的Dmoesin，在果蝇的ERM家族的唯一成员的遗传分析。我们表明，Dmoesin是需要在卵子发生过程中锚定微丝卵母细胞皮质。Dmoesin突变引起的肌动蛋白细胞骨架的改变损害了母体决定簇的定位，从而破坏了前后极性。这项研究还表明，需要Dmoesin的特定组织的皮层微丝在护士细胞，因此，Dmoesin突变产生严重的缺陷，在细胞的形状。
Ezrin, Radixin and Moesin (ERM) proteins are thought to constitute a bridge between the actin cytoskeleton and the plasma membrane (PM). Here we report a genetic analysis of Dmoesin, the sole member of the ERM family in Drosophila. We show that Dmoesin is required during oogenesis for anchoring microfilaments to the oocyte cortex. Alteration of the actin cytoskeleton resulting from Dmoesin mutations impairs the localization of maternal determinants, thus disrupting antero-posterior polarity. This study also demonstrates the requirement of Dmoesin for the specific organization of cortical microfilaments in nurse cells and, consequently, mutations in Dmoesin produce severe defects in cell shape.