Hhip inhibits proliferation and promotes differentiation of adipocytes through suppressing hedgehog signaling pathway
Hhip inhibits proliferation and promotes differentiation of adipocytes through suppressing hedgehog signaling pathway
复制标题
Hhip通过抑制hedgehog信号通路抑制脂肪细胞增殖并促进分化。
DOI：
10.1016/j.bbrc.2019.04.047
复制
发表时间：
2019-06-18
影响因子：
3.1
通讯作者：
Chu, Guiyan
中科院分区：
文献类型：
--
作者：
Wei, Haiyan;Li, Jingjing;Chu, Guiyan
脂肪生成直接控制体脂量，在脂质代谢和肥胖相关疾病中起着至关重要的作用。刺猬相互作用蛋白（Hhip）属于Hedgehog（Hh）信号通路。Hh信号通路在以前的报道中已经与脂肪形成联系在一起，然而，Hhip对脂质沉积的生理功能仍然知之甚少。在本研究中，Hip的水平在猪脂肪组织的发育过程中下调。重组Hedgehog相互作用蛋白（rHhip）可下调S噬菌体中细胞周期相关基因和细胞数量，从而抑制细胞增殖。此外，rHhip可以通过靶向经典Hh信号来增加脂肪细胞分化，这通过增加脂质积累和上调Glut4和PPAR γ表达来表示。总之，这些发现说明了Hhip在脂肪细胞增殖和分化中的重要作用，并为预防肥胖提供了潜在的新靶点。(C)2019爱思唯尔公司All rights reserved.
Adipogenesis, which directly control body fat mass, plays a crucial role in lipid metabolism and obesity-related diseases. Hedgehog interacting protein (Hhip) belongs to Hedgehog (Hh) signaling pathway. The Hh signaling pathway was already linked with adipogenesis in previous reports, however, the physiological functions of Hhip on lipid deposition are still poorly understood. In this study, the level of Hhip was down-regulated during the development of porcine adipose tissues. Recombinant Hedgehog interacting protein (rHhip) could down-regulate cell cycle related genes and cell numbers in S phage to inhibit cell proliferation. Moreover, rHhip could increase adipocytes differentiation by targeting canonical Hh signaling, indicated by the increase of lipid accumulation and up-regulation of Glut4 and PPAR gamma expression. Collectively, these findings illustrated the essential role of Hhip in the proliferation and differentiation of adipocytes, and provided a potential novel target for preventing obesity. (C) 2019 Elsevier Inc. All rights reserved.