Observation of EEG coherence after repetitive transcranial magnetic stimulation
Observation of EEG coherence after repetitive transcranial magnetic stimulation
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DOI：
10.1016/s1388-2457(00)00357-6
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发表时间：
2000-09-01
影响因子：
4.7
通讯作者：
Takigawa, M
中科院分区：
文献类型：
--
作者：
Jing, HK;Takigawa, M
目的：方法：19名健康受试者接受两次重复经颅磁刺激（rTMS）（10 Hz，100%运动阈，3s/train），刺激左侧额叶，观察rTMS前后脑电活动的变化。定向相干性和普通相干性计算之前和之后（1类似于3和3类似于5分钟）rTMS记录的EEG时期。结果：经颅磁刺激后，大脑皮质区间的定向相干性增强（F = 5.62，P < 0.005），且半球内的变化比半球间的变化更明显。从刺激部位到其他部位的连接被选择性地加强。与此相反，普通的连贯性并没有改变后的刺激。rTMS不影响计算最大相干性的主频。rTMS后与rTMS前比较，两种刺激方式下的同向一致性差异有显著性意义（r = 0.88，0.89，P < 0.001）。结论：（1）rTMS可增强皮质区之间的联系，尤其是刺激皮质与脑内其他部位的联系。(2)与顶区到额区的联系相比，额区到顶区的联系在两半球都得到了明显的改善。(3)rTMS的效果可以持续几分钟。因此，建议在rTMS研究中进行EEG监测的必要性。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
Objective: The effects before and after repetitive transcranial magnetic stimulation (rTMS) on EEG activity were investigated.Methods: Nineteen healthy subjects received two trains (10 Hz, 100% of motor threshold, 3 s/train) of rTMS to the left frontal area. Directed coherence and ordinary coherence were calculated from EEG epochs recorded before and after (1 similar to 3 and 3 similar to 5 min) rTMS. The results were compared and demonstrated on maps.Results: Directed coherence between cortical areas increased after rTMS (F = 5.62, P < 0.005), with the intra-hemispheric change being more pronounced than the inter-hemispheric change. Connections from the stimulated site to other sites were selectively reinforced. In contrast, ordinary coherence did not change after the stimulation. rTMS did not influence the dominant frequency at which maximal coherence was calculated. Differences in the directed coherence with opposite directions after rTMS were significantly correlated with the differences before rTMS (r = 0.88, 0.89, P < 0.001).Conclusions: (1) rTMS can enhance the connections between cortical areas, especially connections between the stimulated cortex and other sites in the brain. (2) Comparing with connections from the parietal area to frontal area, connections from the frontal area to parietal area are obviously improved by rTMS in both hemispheres. (3) The effects of rTMS can last for several minutes. Therefore, the necessity of EEG monitoring in rTMS studies is suggested. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.