Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
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DOI：
10.1186/1475-2875-7-174
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发表时间：
2008-09-11
期刊：
影响因子：
3
通讯作者：
Tanabe, Kazuyuki
中科院分区：
文献类型：
--
作者：
Culleton, Richard L.;Mita, Toshihiro;Tanabe, Kazuyuki
背景：据估计，间日疟原虫每年影响7500万人。然而，据报道，由于达菲阴性表型在土著人口中的高流行率，西非和中非没有这种病毒。尽管如此，非非洲旅行者在访问该地区后返回本国时仍经常携带间日疟。因此，我们试图检测从西非和中非土著居民采集的血液样本中是否存在间日疟原虫寄生虫。通过PCR对从9个非洲疟疾流行国家收集的2，588份血样进行了检测（针对所有4种人类疟原虫）。大多数感染（98.5%）为恶性疟原虫，三日疟原虫占所有感染的8.5%，卵形疟原虫占3.9%。这两种寄生虫的流行率因国家而异。只有一例间日疟原虫被检测到从圣托姆，非洲西海岸的一个岛屿，证实了这种寄生虫在Africa.Conclusion稀缺：在撒哈拉以南非洲的当地人群中的流行率间日疟原虫是非常低的，尽管经常确定这种寄生虫在非非洲旅行者。
Background: Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. vivax malaria after visiting this region. An attempt was made, therefore, to detect the presence of P. vivax parasites in blood samples collected from the indigenous populations of west and central Africa.Methods: Parasite species typing (for all four human malaria parasites) was carried out by PCR on 2,588 blood samples collected from individuals from nine African malaria-endemic countries.Results: Most infections (98.5%) were Plasmodium falciparum, Plasmodium malariae was identified in 8.5% of all infections, and Plasmodium ovale in 3.9%. The prevalence of both parasites varied greatly by country. Only one case of P. vivax was detected from Sao Tome, an island off the west coast of Africa, confirming the scarcity of this parasite in Africa.Conclusion: The prevalence of P. vivax in local populations in sub-Saharan Africa is very low, despite the frequent identification of this parasite in non-African travellers.