Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting.
Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting.
复制标题
DOI：
10.1038/msb.2011.101
复制
发表时间：
2012-01-31
影响因子：
9.9
通讯作者：
中科院分区：
文献类型：
--
作者：
Viral infection depends on a complex interplay between host and viral factors. Here, we link host susceptibility to viral infection to a network encompassing sulfur metabolism, tRNA modification, competitive binding, and programmed ribosomal frameshifting (PRF). We first demonstrate that the iron-sulfur cluster biosynthesis pathway in Escherichia coli exerts a protective effect during lambda phage infection, while a tRNA thiolation pathway enhances viral infection. We show that tRNALys uridine 34 modification inhibits PRF to influence the ratio of lambda phage proteins gpG and gpGT. Computational modeling and experiments suggest that the role of the iron-sulfur cluster biosynthesis pathway in infection is indirect, via competitive binding of the shared sulfur donor IscS. Based on the universality of many key components of this network, in both the host and the virus, we anticipate that these findings may have broad relevance to understanding other infections, including viral infection of humans.
登录
查看更多内容
影响因子：
3.2
作者：
Nilsson, K;Lundgren, HK;Björk, GR
通讯作者：
Björk, GR
影响因子：
4.8
作者：
Pierrel, F;Douki, T;Atta, M
通讯作者：
Atta, M
DOI：
10.1093/dnares/5.6.319
发表时间：
1998-12-31
期刊：
DNA research : an international journal for rapid publication of reports on genes and genomes
影响因子：
--
作者：
Kunisawa, T;Kanaya, S;Kutter, E
通讯作者：
Kutter, E
大肠杆菌K-12的构造框架，单基因敲除突变体：Keio Collection。
影响因子：
9.9
作者：
通讯作者：
--
影响因子：
4.3
作者：
Lucks JB;Nelson DR;Kudla GR;Plotkin JB
通讯作者：
Plotkin JB