MECHANISTIC ASPECTS OF GASTRIC [H++K+]-ATPASE
MECHANISTIC ASPECTS OF GASTRIC [H++K+]-ATPASE
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DOI：
10.1111/j.1749-6632.1982.tb25738.x
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发表时间：
1982-01-01
影响因子：
5.2
通讯作者：
SMOLKA, A
中科院分区：
文献类型：
--
作者：
FALLER, L;JACKSON, R;SMOLKA, A
胃酸分泌导致哺乳动物壁细胞分泌小管的pH梯度约为6.6单位。这直接取决于ATP，并且在分离的透化胃腺中没有其他过程可以显示，其中，在将酸分泌共同减少到零的Na 1抑制和缺氧的存在下，添加的ATP能够恢复分泌。'.在这些分离的腺体中，就像在完整的胃中一样，分泌也依赖于K和C1-的存在。随着ATP酶的分离，它被K+刺激，并以囊泡形式能够泵送质子，似乎胃分泌酸的一般机制已经建立？在本文中，我们将讨论一些已阐明的胃ATP酶的机制方面，显示与研究得更好的Na+ K+-和Ca”-ATP酶的相似性和差异。
Gastric acid secretion results in a pH gradient of about 6.6 units across the secretory canaliculus of the mammalian parietal cell. That this depends directly on ATP and no other process can be shown in isolated, permeabilized gastric glands where, in the presence of mitochondria1 inhibition and anoxia, which collectively reduce acid secretion to zero, added ATP is able to restore secretion.'.'In these isolated glands, as in the intact stomach, secretion is also dependent on the presence of K'and C1-. With the isolation of an ATPase that was K+ stimulated and in vesicular form was able to pump protons, it would appear that the general mechanism for acid secretion by the stomach was established?-'In this paper we will discuss some of the mechanistic aspects of the gastric ATPase that have been elucidated, showing both similarities to and differences from the better studied Na+ K+-and Ca"-ATPases.