CHEMOSURGERY FOR THE MICROSCOPICALLY CONTROLLED EXCISION OF CUTANEOUS CANCER
CHEMOSURGERY FOR THE MICROSCOPICALLY CONTROLLED EXCISION OF CUTANEOUS CANCER
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DOI：
10.1002/hed.2890010209
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发表时间：
1978-01-01
期刊：
影响因子：
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通讯作者：
MOHS, FE
中科院分区：
文献类型：
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作者：
MOHS, FE
皮肤癌和其他可触及结构的癌可以在完全显微镜控制下切除，如果癌区域被逐层切除，并且如果每层的下表面然后通过系统地使用冷冻切片在显微镜下检查。如果癌症是广泛的和复杂的，或者如果肿瘤是一种容易扩散的类型，在切除每一层之前，用氯化锌将组织原位固定（固定组织技术）。如果癌症不是过于广泛或复杂，组织层在新鲜，未固定状态下切除（新鲜组织技术）。这两种方法都非常可靠。在两个连续的基底细胞癌化疗系列中，通过固定组织技术切除的9，351个病灶的5年治愈率为99.3%，通过新鲜组织方法切除的196个病灶的5年治愈率为98.1%。
Cancer of the skin and of other accessible structures can be removed under complete microscopic control if the cancerous area is excised layer by layer, and if the undersurface of each layer is then examined under the microscope through systematic use of frozen sections. If the cancer is extensive and complicated, or if the neoplasm is of a type that is readily disseminated, the tissues are fixed in situ with zinc chloride prior to the excision of each layer (fixed‐tissue technique). If the cancer is not overly extensive or complicated, the layers of tissue are excised in the fresh, unfixed state (fresh‐tissue technique). Both methods are highly reliable. In two consecutive series of basal‐cell carcinomas treated chemosurgically, the five‐year cure rate achieved was 99.3% for the 9,351 lesions removed by the fixed‐tissue technique, and 98.1% for the 196 lesions removed by the fresh‐tissue method.