Prefrontal grey-matter changes in short-term and long-term abstinent methamphetamine abusers
Prefrontal grey-matter changes in short-term and long-term abstinent methamphetamine abusers
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DOI：
10.1017/s1461145705005699
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发表时间：
2006-04-01
影响因子：
4.8
通讯作者：
Renshaw, PF
中科院分区：
文献类型：
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作者：
Kim, SJ;Lyoo, IK;Renshaw, PF
作者使用基于体素的形态测定法探索了 29 名甲基苯丙胺滥用者和 20 名健康对照受试者的灰质密度。还比较了 11 名短期（< 6 个月）和 18 名长期（>= 6 个月）戒除甲基苯丙胺滥用者的灰质密度变化和威斯康星卡片分类测试 (WCST) 表现。与健康对照受试者相比，甲基苯丙胺滥用者的右中额叶皮层灰质密度较低（校正后 p < 0.05），WCST 总误差较多（p < 0.01）。甲基苯丙胺滥用者右中额叶皮层灰质密度下降与 WCST 总误差相关 (r = -0.45)。与短期禁欲滥用者相比，长期禁欲滥用者的右中额叶灰质密度下降（p < 0.01）和 WCST 总误差（p < 0.01）显着较少，但高于健康对照受试者。我们报告称，甲基苯丙胺滥用者存在前额叶灰质缺陷，这种缺陷可能会通过长期戒毒而部分恢复。
Authors explored grey-matter density in 29 methamphetamine abusers and 20 healthy comparison Subjects using voxel-based morphometry. Grey-matter density changes and performances on the Wisconsin Card Sorting test (WCST) were also compared between 11 short-term(< 6 months)and 18 longterm (>= 6 months) abstinent methamphetamine abusers. Methaniphetamine abusers had lower greymatter density in the right middle frontal cortex (corrected p < 0.05) and more total errors in the WCST (p < 0.01)relative to healthy comparison subjects. Grey-matter density decrease in the right middle frontal cortex correlated with total errors in the WCST in methamphetamine abusers (r = -0.45). Long-tern) abstinent abusers had significantly less right middle frontal grey-matter density decrease (p < 0.01) and total errors in the WCST (p < 0.01) than short-term abstinent abusers, but more than the healthy comparison subjects. We report that methamphetamine abusers have prefrontal grey-matter deficit, which may, in part, recover with long-term abstinence.